Date published: 2025-12-7

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5-Aminovaleric acid (CAS 660-88-8)

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Alternate Names:
Homopiperidinic acid
CAS Number:
660-88-8
Purity:
≥97%
Molecular Weight:
117.15
Molecular Formula:
C5H11NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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5-Aminovaleric acid serves as a substrate in enzymatic assays, facilitating the measurement of enzyme activity, particularly for serine proteases. Additionally, it finds application in the exploration of protein structure and function. 5-Aminovaleric acid is recognized as an agonist, capable of activating specific serotonin receptors within the brain.


5-Aminovaleric acid (CAS 660-88-8) References

  1. Synthesis and structural study of cyclic 5-aminovaleric acid-linked beta-Ala-beta-Ala dipeptides.  |  Mengel, A., et al. 2008. Bioorg Med Chem Lett. 18: 5975-7. PMID: 18682325
  2. Phagocytosis of biocompatible gold nanoparticles.  |  Krpetić, Z., et al. 2010. Langmuir. 26: 14799-805. PMID: 20795674
  3. 5-aminovaleric acid suppresses the development of severe seizures in the methionine sulfoximine model of mesial temporal lobe epilepsy.  |  Dhaher, R., et al. 2014. Neurobiol Dis. 67: 18-23. PMID: 24632421
  4. Metabolic engineering of Corynebacterium glutamicum for enhanced production of 5-aminovaleric acid.  |  Shin, JH., et al. 2016. Microb Cell Fact. 15: 174. PMID: 27717386
  5. Application of an Acyl-CoA Ligase from Streptomyces aizunensis for Lactam Biosynthesis.  |  Zhang, J., et al. 2017. ACS Synth Biol. 6: 884-890. PMID: 28414905
  6. Production of 5-aminovaleric acid in recombinant Corynebacterium glutamicum strains from a Miscanthus hydrolysate solution prepared by a newly developed Miscanthus hydrolysis process.  |  Joo, JC., et al. 2017. Bioresour Technol. 245: 1692-1700. PMID: 28579174
  7. 5-Aminovaleric acid interactions with GABAA and GABAB receptors in guinea-pig ileum.  |  Luzzi, S., et al. 1985. J Auton Pharmacol. 5: 65-9. PMID: 2985620
  8. Production of glutaric acid from 5-aminovaleric acid using Escherichia coli whole cell bio-catalyst overexpressing GabTD from Bacillus subtilis.  |  Hong, YG., et al. 2018. Enzyme Microb Technol. 118: 57-65. PMID: 30143200
  9. Enhanced production of glutaric acid by NADH oxidase and GabD-reinforced bioconversion from l-lysine.  |  Hong, YG., et al. 2019. Biotechnol Bioeng. 116: 333-341. PMID: 30450795
  10. Production of glutaric acid from 5-aminovaleric acid by robust whole-cell immobilized with polyvinyl alcohol and polyethylene glycol.  |  Yang, SY., et al. 2019. Enzyme Microb Technol. 128: 72-78. PMID: 31186113
  11. Development of glutaric acid production consortium system with α-ketoglutaric acid regeneration by glutamate oxidase in Escherichia coli.  |  Yang, SY., et al. 2020. Enzyme Microb Technol. 133: 109446. PMID: 31874692
  12. Complexation of 5-aminovaleric acid zwitterions in aqueous/methanol solution by heterotopic tri-cationic receptors.  |  Walczak, W., et al. 2020. Org Biomol Chem. 18: 694-699. PMID: 31904059
  13. [Identification of 5-aminovaleric acid as a characteristic product of metabolism of various Clostridium species].  |  Rodionov, AV., et al. 1988. Bioorg Khim. 14: 944-51. PMID: 3190778
  14. Enhancing glutaric acid production in Escherichia coli by uptake of malonic acid.  |  Sui, X., et al. 2020. J Ind Microbiol Biotechnol. 47: 311-318. PMID: 32140931
  15. Metabolomic Analyses to Identify Candidate Biomarkers of Cystinosis.  |  Nemutlu, E., et al. 2023. Int J Mol Sci. 24: PMID: 36768921

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

5-Aminovaleric acid, 5 g

sc-239025
5 g
$49.00