Molecular structure of 5,7-Dichlorokynurenic acid, CAS Number: 131123-76-7
5,7-Dichlorokynurenic acid (CAS 131123-76-7)
Application:
5,7-Dichlorokynurenic acid is a potent NMDA receptor glycine binding site antagonist
CAS Number:
131123-76-7
Molecular Weight:
258.06
Molecular Formula:
C10H5Cl2NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
5,7-Dichlorokynurenic acid is a derivative of the excitatory amino acid kynurenic acid and an antagonist of the strychnine-insensitive glycine modulatory (co-agonist) binding site on the NMDA receptor. 5,7-Dichlorokynurenic acid is described to potently and noncompetitively antagonize NMDA-stimulated elevation of cytosolic Ca2+, accumulation of cGMP, and release of norepinephrine. 5,7-Dichlorokynurenic acid is an inhibitor of GluR.
5,7-Dichlorokynurenic acid (CAS 131123-76-7) References
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- Support for radiolabeling of a glycine recognition domain on the N-methyl-D-aspartate receptor ionophore complex by 5,7-[3H]dichlorokynurenate in rat brain. | Yoneda, Y., et al. 1993. J Neurochem. 60: 634-45. PMID: 8419541
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Inhibitor of:
GluR, GlyR α1 (GLRA1), NMDA, and NP60.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
5,7-Dichlorokynurenic acid, 10 mg | sc-200440 | 10 mg | $74.00 | |||
5,7-Dichlorokynurenic acid, 50 mg | sc-200440A | 50 mg | $409.00 |