4′-epi-Daunorubicin (CAS 57918-24-8)
CAS Number:
57918-24-8
Molecular Weight:
527.52
Molecular Formula:
C27H29NO10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
4′-epi-Daunorubicin Hydrochloride, referred to as 4′-epi-DNR HCl, is an analog of the compound daunorubicin. It is known for its red color and crystalline form when isolated. In research applications, this compound has been explored for its interactions with DNA, where it can intercalate between DNA strands. These interactions make it a subject of interest in studies related to molecular biology and genetics, particularly in understanding DNA behavior and stability under various conditions.
4′-epi-Daunorubicin (CAS 57918-24-8) References
- Formaldehyde-induced alkylation of a 2'-aminoglucose rebeccamycin derivative to both A.T and G.C base pairs in DNA. | Bailly, C., et al. 2000. J Med Chem. 43: 4711-20. PMID: 11101362
- Synthesis and antitumor properties of new glycosides of daunomycinone and adriamycinone. | Arcamone, F., et al. 1975. J Med Chem. 18: 703-7. PMID: 168385
- Natural-product sugar biosynthesis and enzymatic glycodiversification. | Thibodeaux, CJ., et al. 2008. Angew Chem Int Ed Engl. 47: 9814-59. PMID: 19058170
- Development of a Streptomyces venezuelae-based combinatorial biosynthetic system for the production of glycosylated derivatives of doxorubicin and its biosynthetic intermediates. | Han, AR., et al. 2011. Appl Environ Microbiol. 77: 4912-23. PMID: 21602397
- Bioconversion of deoxysugar moieties to the biosynthetic intermediates of daunorubicin in an engineered strain of Streptomyces coeruleobidus. | Yuan, T., et al. 2014. Biotechnol Lett. 36: 1809-18. PMID: 24793498
- Relationship between activity and amino sugar stereochemistry of daunorubicin and adriamycin derivatives. | Di Marco, A., et al. 1976. Cancer Res. 36: 1962-6. PMID: 773533
- Production of the antitumor drug epirubicin (4'-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius. | Madduri, K., et al. 1998. Nat Biotechnol. 16: 69-74. PMID: 9447597
- Binding of the modified daunorubicin WP401 adjacent to a T-G base pair induces the reverse Watson-Crick conformation: crystal structures of the WP401-TGGCCG and WP401-CGG[br5C]CG complexes. | Dutta, R., et al. 1998. Nucleic Acids Res. 26: 3001-5. PMID: 9611247
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4′-epi-Daunorubicin, 0.5 mg | sc-499939 | 0.5 mg | $849.00 | |||
4′-epi-Daunorubicin, 5 mg | sc-499939A | 5 mg | $3200.00 |