Molecular structure of 4-Pyridoxic acid, CAS Number: 82-82-6
4-Pyridoxic acid (CAS 82-82-6)
Alternate Names:
2-Methyl-3-hydroxy-4-carboxy-5-hydroxymethylpyridine; 3-Hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxylic acid
Application:
4-Pyridoxic acid is a catabolite of vitamin B6
CAS Number:
82-82-6
Purity:
≥98%
Molecular Weight:
183.16
Molecular Formula:
C8H9NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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4-Pyridoxic acid is a primary metabolite of vitamin B6 and is a compound used in nutritional and metabolic research to assess vitamin B6 status in biological specimens. Researchers employ it as a biomarker in epidemiological studies to investigate the correlation between vitamin B6 levels and various health conditions, relying on its presence in urine as an indicator of the body′s vitamin B6 reserves. In enzymology, 4-pyridoxic acid is also used to study the activity of aldehyde oxidase and xanthine dehydrogenase, as it serves as a substrate for these enzymes. Furthermore, its role in elucidating the transport mechanisms of organic anions in renal systems is notable, as it assists in understanding the renal excretion of metabolites.
4-Pyridoxic acid (CAS 82-82-6) References
- Elevated plasma 4-pyridoxic acid in renal insufficiency. | Coburn, SP., et al. 2002. Am J Clin Nutr. 75: 57-64. PMID: 11756060
- B-6 vitamers and 4-pyridoxic acid in the plasma, erythrocytes, and urine of postmenopausal women. | Massé, PG., et al. 2004. Am J Clin Nutr. 80: 946-51. PMID: 15447904
- Clinical analysis of vitamin B(6): determination of pyridoxal 5'-phosphate and 4-pyridoxic acid in human serum by reversed-phase high-performance liquid chromatography with chlorite postcolumn derivatization. | Rybak, ME. and Pfeiffer, CM. 2004. Anal Biochem. 333: 336-44. PMID: 15450810
- PLP catabolism: identification of the 4-pyridoxic acid dehydrogenase gene in Mesorhizobium loti MAFF303099. | Mukherjee, T., et al. 2007. Bioorg Chem. 35: 458-64. PMID: 17868768
- Topology of 4-Pyridoxic acid dehydrogenase in transformed Escherichia coli cells. | Ge, F. and Yagi, T. 2010. J Biochem. 147: 291-5. PMID: 19861399
- Contents of all forms of vitamin B6, pyridoxine-β-glucoside and 4-pyridoxic acid in mature milk of Japanese women according to 4-pyridoxolactone-conversion high performance liquid chromatography. | Yagi, T., et al. 2013. J Nutr Sci Vitaminol (Tokyo). 59: 9-15. PMID: 23535534
- Measurement of pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid in the cerebrospinal fluid of children. | Akiyama, T., et al. 2017. Clin Chim Acta. 466: 1-5. PMID: 28040557
- Pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid in the paired serum and cerebrospinal fluid of children. | Akiyama, T., et al. 2017. Clin Chim Acta. 472: 118-122. PMID: 28778380
- Menstrual cycle rhythmicity: metabolic patterns in healthy women. | Draper, CF., et al. 2018. Sci Rep. 8: 14568. PMID: 30275458
- A novel hydrophilic interaction chromatography assay characterization of 4-pyridoxic acid, an emergent renal organic anion transporter 1/3 transporter biomarker. | Towner, J., et al. 2021. Bioanalysis. 13: 1391-1400. PMID: 34551579
- Determination of urinary 4-pyridoxic acid levels as 4-pyridoxic acid lactone using high-performance liquid chromatography. | Ubbink, JB., et al. 1986. Am J Clin Nutr. 44: 698-703. PMID: 3766456
- Excretion of 4-pyridoxic acid and oxalic acid in patients with urinary calculi. | Tiselius, HG. 1977. Invest Urol. 15: 5-8. PMID: 873737
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-Pyridoxic acid, 25 mg | sc-232980 | 25 mg | $86.00 | |||
4-Pyridoxic acid, 100 mg | sc-232980A | 100 mg | $162.00 |