Molecular structure of 4-P-PDOT, CAS Number: 134865-74-0
4-P-PDOT (CAS 134865-74-0)
See product citations (3)
Alternate Names:
AH 024; cis-4-Phenyl-2-propionamidotetralin
Application:
4-P-PDOT is a MEL-1B-R melatonin receptor antagonist
CAS Number:
134865-74-0
Molecular Weight:
279.38
Molecular Formula:
C19H21NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
4-P-PDOT (4-Phenyl-2-propionamidotetralin) is a synthetic compound known for its biological activity as a selective antagonist of the melatonin MT2 receptor. Melatonin receptors, which include MT1 and MT2 subtypes, are part of the G protein-coupled receptor (GPCR) family and are activated by the hormone melatonin. These receptors play a role in regulating circadian rhythms, sleep-wake cycles, and various other physiological processes.
4-P-PDOT (CAS 134865-74-0) References
- An improved synthesis of cis-4-phenyl-2-propionamidotetralin (4-P-PDOT): a selective MT(2) melatonin receptor antagonist. | Lucarini, S., et al. 2008. Org Biomol Chem. 6: 147-50. PMID: 18075659
- Toward the definition of stereochemical requirements for MT2-selective antagonists and partial agonists by studying 4-phenyl-2-propionamidotetralin derivatives. | Bedini, A., et al. 2011. J Med Chem. 54: 8362-72. PMID: 22047556
- The influence od melatonin receptors antagonists, luzindole and 4-phenyl-2-propionamidotetralin (4-P-PDOT), on melatonin-dependent vasopressin and adrenocorticotropic hormone (ACTH) release from the rat hypothalamo-hypophysial system. In vitro and in vivo studies. | Juszczak, M., et al. 2014. J Physiol Pharmacol. 65: 777-84. PMID: 25554981
- The role of melatonin membrane receptors in melatonin-dependent oxytocin secretion from the rat hypothalamo-neurohypophysial system - an in vitro and in vivo approach. | Juszczak, M., et al. 2016. Endokrynol Pol. 67: 507-514. PMID: 26884304
- Stimulatory Effects of Melatonin on Porcine In Vitro Maturation Are Mediated by MT2 Receptor. | Lee, S., et al. 2018. Int J Mol Sci. 19: PMID: 29861447
- Melatonin Attenuates Anoxia/Reoxygenation Injury by Inhibiting Excessive Mitophagy Through the MT2/SIRT3/FoxO3a Signaling Pathway in H9c2 Cells. | Wu, J., et al. 2020. Drug Des Devel Ther. 14: 2047-2060. PMID: 32546969
- Melatonin Improves the Resistance of Oxidative Stress-Induced Cellular Senescence in Osteoporotic Bone Marrow Mesenchymal Stem Cells. | Chen, W., et al. 2022. Oxid Med Cell Longev. 2022: 7420726. PMID: 35087617
- Melatonin Prevents Cartilage Degradation in Early-Stage Osteoarthritis Through Activation of miR-146a/NRF2/HO-1 Axis. | Zhou, X., et al. 2022. J Bone Miner Res. 37: 1056-1072. PMID: 35147250
- Melatonin Inhibits NF-κB/CREB/Runx2 Signaling and Alleviates Aortic Valve Calcification. | Li, SJ., et al. 2022. Front Cardiovasc Med. 9: 885293. PMID: 35795373
- Mammalian Melatonin Agonist Pharmaceuticals Stimulate Rhomboid Proteins in Plants. | Erland, LAE., et al. 2022. Biomolecules. 12: PMID: 35883439
- Melatonin inhibits muscular-mucosal stretch-sensitive bladder afferents via the MT2 receptors. | Ramsay, S. and Zagorodnyuk, V. 2022. Sci Rep. 12: 17686. PMID: 36271291
- High and low dose of luzindole or 4-phenyl-2-propionamidotetralin (4-P-PDOT) reverse bovine granulosa cell response to melatonin. | Liu, W., et al. 2023. PeerJ. 11: e14612. PMID: 36684672
- Melatonin receptors: are there multiple subtypes? | Dubocovich, ML. 1995. Trends Pharmacol Sci. 16: 50-6. PMID: 7762083
- Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor. | Dubocovich, ML., et al. 1997. Naunyn Schmiedebergs Arch Pharmacol. 355: 365-75. PMID: 9089668
Inhibitor of:
MEL-1B-R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-P-PDOT, 10 mg | sc-361083 | 10 mg | $140.00 | |||
4-P-PDOT, 50 mg | sc-361083A | 50 mg | $552.00 |