4-Hydroxy Omeprazole Sulfide (CAS 103876-98-8)

4-Hydroxy Omeprazole Sulfide is a metabolite of omeprazole, extensively studied in biochemical and pharmacological research for its role in understanding the metabolic pathways and mechanisms of action of proton pump inhibitors (PPIs). The chemical mechanism involves the reduction of the sulfoxide group of omeprazole to a sulfide, followed by hydroxylation at the fourth position, producing 4-Hydroxy Omeprazole Sulfide. This metabolite is significant in the study of cytochrome P450 (CYP) enzyme activity, particularly CYP2C19 and CYP3A4, which are responsible for the biotransformation of omeprazole in the liver. In research, 4-Hydroxy Omeprazole Sulfide is used as a probe to investigate the kinetic properties of these CYP enzymes and to understand the genetic polymorphisms that affect drug metabolism. Studies using this metabolite help explain the variability in drug response among different populations, providing insights into personalized medicine approaches. Additionally, it serves as a model compound in drug-drug interaction studies, as its formation and clearance can be influenced by co-administered drugs that either inhibit or induce CYP enzymes. Moreover, 4-Hydroxy Omeprazole Sulfide is employed in the development and validation of analytical methods, such as liquid chromatography-mass spectrometry (LC-MS), for the quantification of drug metabolites in biological samples. These studies contribute to a comprehensive understanding of the metabolic fate of PPIs and their impact on drug efficacy and safety.