Date published: 2025-10-31

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4-Hexyn-3-ol (CAS 20739-59-7)

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CAS Number:
20739-59-7
Molecular Weight:
98.14
Molecular Formula:
C6H10O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Hexyn-3-ol (4H3O) is a volatile organic compound (VOC). It presents as a colorless liquid with a subtle odor and possesses solubility in water. As a member of the aliphatic alcohol family, characterized by the presence of an alkyl group (C-H) attached to a hydroxyl group (OH), 4-Hexyn-3-ol exhibits versatility and finds utility in chemical synthesis, as a solvent, and as a biomarker for environmental monitoring. In-depth investigations have explored the potential applications of 4-Hexyn-3-ol in diverse scientific domains. In the field of chemistry, 4-Hexyn-3-ol has proven useful as a solvent and a reactant in various chemical reactions. Its involvement extends to the field of biochemistry, where it has served as a substrate for enzymes and as a marker for metabolic pathways. The precise mechanism of action of 4-Hexyn-3-ol remains partially elusive, yet it is believed to be closely linked to its chemical structure. Being an aliphatic alcohol, the molecule possesses an alkyl group (C-H) attached to a hydroxyl group (OH). This structural arrangement renders 4-Hexyn-3-ol a polar molecule capable of engaging in interactions with other molecules and forming hydrogen bonds. Consequently, this property enables 4-Hexyn-3-ol to function as a solvent and actively participate in diverse chemical reactions.


4-Hexyn-3-ol (CAS 20739-59-7) References

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  2. Semi-field evaluation of several novel alkenol analogs of 1-octen-3-ol as attractants to adult Aedes albopictus and Culex quinquefasciatus.  |  Cilek, JE., et al. 2011. J Am Mosq Control Assoc. 27: 256-62. PMID: 22017090
  3. Does activation of the anti proton, rather than concertedness, determine the stereochemistry of base-catalyzed 1,2-elimination reactions? Anti stereospecificity in E1cB eliminations of β-3-trifluoromethylphenoxy esters, thioesters, and ketones.  |  Mohrig, JR., et al. 2012. J Org Chem. 77: 2819-28. PMID: 22321002
  4. Conformational effect on the almost free internal rotation in 4-hexyn-3-ol studied by microwave spectroscopy and quantum chemistry.  |  Eibl, K., et al. 2018. J Chem Phys. 149: 144306. PMID: 30316265
  5. A strong dependence of the CH3 internal rotation barrier on conformation in thioacetic acid: Microwave measurements and an energy decomposition analysis.  |  Smith, CJ., et al. 2019. J Chem Phys. 150: 134302. PMID: 30954056
  6. Thiol-yne Click Post-Modification for the Synthesis of Chiral Microporous Organic Networks for Chiral Gas Chromatography.  |  Cui, YY., et al. 2020. ACS Appl Mater Interfaces. 12: 4954-4961. PMID: 31894954
  7. Internal Rotation of the Acetyl Methyl Group in Methyl Alkyl Ketones: The Microwave Spectrum of Octan-2-one.  |  Andresen, M., et al. 2020. Chemphyschem. 21: 2206-2216. PMID: 32658351
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Hexyn-3-ol, 1 g

sc-226667
1 g
$199.00