Date published: 2026-1-20

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4-Chlorocatechol (CAS 2138-22-9)

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Application:
4-Chlorocatechol is a chloro-substituted catechol compound
CAS Number:
2138-22-9
Molecular Weight:
144.56
Molecular Formula:
ClC6H3(OH)2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Chlorocatechol is a chloro-substituted catechol compound. 4-Chlorocatechol is described as a substrate and probe for catechol 1,2-dioxygenase and chlorocatechol dioxygenase enzyme activity. It may also be useful as a fragment for the synthesis of more elaborate catechol compounds.


4-Chlorocatechol (CAS 2138-22-9) References

  1. 4-Chlorocatechol 1,2-dioxygenase from the chlorophenol-utilizing Gram-positive Rhodococcus opacus 1CP: crystallization and preliminary crystallographic analysis.  |  Ferraroni, M., et al. 2002. Acta Crystallogr D Biol Crystallogr. 58: 1074-6. PMID: 12037322
  2. New bacterial pathway for 4- and 5-chlorosalicylate degradation via 4-chlorocatechol and maleylacetate in Pseudomonas sp. strain MT1.  |  Nikodem, P., et al. 2003. J Bacteriol. 185: 6790-800. PMID: 14617643
  3. Crystal structure of 4-chlorocatechol 1,2-dioxygenase from the chlorophenol-utilizing gram-positive Rhodococcus opacus 1CP.  |  Ferraroni, M., et al. 2004. J Biol Chem. 279: 27646-55. PMID: 15060064
  4. Fine-tuning of catalytic properties of catechol 1,2-dioxygenase by active site tailoring.  |  Caglio, R., et al. 2009. Chembiochem. 10: 1015-24. PMID: 19301316
  5. Characterization of a gene cluster involved in 4-chlorocatechol degradation by Pseudomonas reinekei MT1.  |  Cámara, B., et al. 2009. J Bacteriol. 191: 4905-15. PMID: 19465655
  6. X-ray structures of 4-chlorocatechol 1,2-dioxygenase adducts with substituted catechols: new perspectives in the molecular basis of intradiol ring cleaving dioxygenases specificity.  |  Ferraroni, M., et al. 2013. J Struct Biol. 181: 274-82. PMID: 23261399
  7. Novel degradation pathway of 4-chloro-2-aminophenol via 4-chlorocatechol in Burkholderia sp. RKJ 800.  |  Arora, PK., et al. 2014. Environ Sci Pollut Res Int. 21: 2298-2304. PMID: 24057966
  8. Optimization and reconstruction of two new complete degradation pathways for 3-chlorocatechol and 4-chlorocatechol in Escherichia coli.  |  Wang, B., et al. 2021. J Hazard Mater. 419: 126428. PMID: 34171665
  9. Enhanced Bioremediation of 4-Chlorophenol by Electrically Neutral Reactive Species Generated from Nonthermal Atmospheric-Pressure Plasma.  |  Kato, H., et al. 2022. ACS Omega. 7: 16197-16203. PMID: 35571825
  10. Regiospecific Oxidation of Chlorobenzene to 4-Chlororesorcinol, Chlorohydroquinone, 3-Chlorocatechol and 4-Chlorocatechol by Engineered Toluene o-Xylene Monooxygenases.  |  Yanık-Yıldırım, KC., et al. 2022. Appl Environ Microbiol. 88: e0035822. PMID: 35736230
  11. Bacterial metabolism of 4-chlorophenoxyacetate.  |  Evans, WC., et al. 1971. Biochem J. 122: 509-17. PMID: 5123884
  12. From xenobiotic to antibiotic, formation of protoanemonin from 4-chlorocatechol by enzymes of the 3-oxoadipate pathway.  |  Blasco, R., et al. 1995. J Biol Chem. 270: 29229-35. PMID: 7493952
  13. Metabolism of 4-chlorophenol by Azotobacter sp. GP1: structure of the meta cleavage product of 4-chlorocatechol.  |  Wieser, M., et al. 1994. FEMS Microbiol Lett. 116: 73-8. PMID: 8132157

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Chlorocatechol, 1 g

sc-232599
1 g
$103.00