Date published: 2025-9-25

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4-Chlorobenzyl chloride (CAS 104-83-6)

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Alternate Names:
1-Chloro-4-(chloromethyl)benzene; p-Chlorobenzyl chloride
Application:
4-Chlorobenzyl chloride is A reagent used in derivatization
CAS Number:
104-83-6
Molecular Weight:
161.03
Molecular Formula:
C7H6Cl2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Chlorobenzyl chloride is a versatile organochloride compound used extensively in organic synthesis, particularly as an intermediate for producing various chemicals, dyes, pharmaceuticals, and agrochemicals. Its molecular structure features a benzene ring substituted with both a chlorine atom and a benzyl chloride group, enhancing its reactivity and making it suitable for benzylation reactions where it acts as an alkylating agent. This functionality allows 4-chlorobenzyl chloride to participate in nucleophilic substitution reactions, where the benzyl chloride group, which includes a good leaving group (the chloride), can readily form new bonds with nucleophilic entities. In research settings, this compound facilitates the exploration of complex synthetic pathways, aids in the development of novel chemical synthesis techniques, and helps in understanding reaction mechanisms, particularly those involving the transfer of benzyl groups to various substrates. The chemical′s reactivity and utility in creating more complex molecules make it a critical subject of study in organic chemistry, contributing significantly to advancements in industrial chemical production and materials science.


4-Chlorobenzyl chloride (CAS 104-83-6) References

  1. Synthesis, spectral analysis and biological evaluation of Nalkyl/aralkyl/aryl-4-chlorobenzenesulfonamide derivatives.  |  Rehman, A., et al. 2016. Pak J Pharm Sci. 29: 1489-1496. PMID: 27731801
  2. Crystal structure, Hirshfeld surface analysis and DFT studies of 5-(adamantan-1-yl)-3-[(4-chlorobenzyl)sulfanyl]-4-methyl-4H-1,2,4-triazole, a potential 11β-HSD1 inhibitor.  |  Al-Wahaibi, LH., et al. 2019. Sci Rep. 9: 19745. PMID: 31875009
  3. Design, synthesis and biological evaluation of spiropyrazolopyridone derivatives as potent dengue virus inhibitors.  |  Xu, J., et al. 2020. Bioorg Med Chem Lett. 30: 127162. PMID: 32247736
  4. Synthesis and Structure Elucidation of New Benzimidazole Amidoxime Derivatives.  |  Karaaslan, C. 2020. Turk J Pharm Sci. 17: 108-114. PMID: 32454768
  5. Convenient Novel Method to Access N-Benzylated Isatoic Anhydride: Reaction Behavior of Isatoic Anhydride with 4-Chlorobenzyl Chloride in the Presence of Bases.  |  Verma, E., et al. 2021. ACS Omega. 6: 8346-8355. PMID: 33817495
  6. Investigation of halloysite nanotubes and Schiff base combination with deposited copper iodide nanoparticles as a novel heterogeneous catalytic system.  |  Daraie, M., et al. 2021. Sci Rep. 11: 23658. PMID: 34880320
  7. Sequential analysis for identification of byproduct from N-benzylation reaction: wound healing and anti-inflammatory potential of the byproduct 4-chlorobenzyl 2-((4-chlorobenzyl)amino)benzoate.  |  Verma, E., et al. 2023. RSC Adv. 13: 25904-25911. PMID: 37655349
  8. Synthesis and cytotoxic activity evaluation of novel imidazopyridine carbohydrazide derivatives.  |  Firouzi, M., et al. 2024. BMC Chem. 18: 6. PMID: 38184605

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Chlorobenzyl chloride, 100 g

sc-254647
100 g
$29.00

4-Chlorobenzyl chloride, 500 g

sc-254647A
500 g
$79.00