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4-Chloro-2-methylaniline (CAS 95-69-2)

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Alternate Names:
2-Amino-5-chlorotoluene; 4-Chloro-o-toluidine
CAS Number:
95-69-2
Molecular Weight:
141.60
Molecular Formula:
C7H8ClN
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Chloro-2-methylaniline is a chemical compound that functions as a substrate in various organic synthesis reactions. It acts as a precursor in the production of dyes, and agrochemicals. 4-Chloro-2-methylaniline undergoes electrophilic aromatic substitution reactions, where the chlorine atom on the benzene ring is replaced by other functional groups, leading to the formation of diverse chemical products. In development, 4-Chloro-2-methylaniline serves as a building block for the synthesis of complex organic molecules, enabling the creation of new materials and compounds with specific properties. Its mechanism of action involves participating in chemical reactions that result in the modification of its molecular structure, allowing for the generation of a wide range of derivatives with potential applications in various fields of study.


4-Chloro-2-methylaniline (CAS 95-69-2) References

  1. Comparative investigation of multiple organs of mice and rats in the comet assay.  |  Sekihashi, K., et al. 2002. Mutat Res. 517: 53-75. PMID: 12034309
  2. Determination of dichloroanilines in human urine by gas chromatography/mass spectrometry: validation protocol and establishment of Reference Values in a population group living in central Italy.  |  Turci, R., et al. 2006. Rapid Commun Mass Spectrom. 20: 2621-5. PMID: 16897789
  3. Degradation of 2-methylaniline and chlorinated isomers of 2-methylaniline by Rhodococcus rhodochrous strain CTM.  |  Fuchs, K., et al. 1991. J Gen Microbiol. 137: 2033-9. PMID: 1955877
  4. Vibrational spectroscopy [FTIR and FTRaman] investigation, computed vibrational frequency analysis and IR intensity and Raman activity peak resemblance analysis on 4-chloro 2-methylaniline using HF and DFT [LSDA, B3LYP and B3PW91] calculations.  |  Ramalingam, S. and Periandy, S. 2011. Spectrochim Acta A Mol Biomol Spectrosc. 78: 1149-61. PMID: 21237700
  5. p-Chloro-o-toluidine and its hydrochloride.  |  ,. 2011. Rep Carcinog. 12: 104-6. PMID: 21850149
  6. Sensitive determination of chloroanilines in water samples by hollow fiber-based liquid-phase microextraction prior to capillary electrophoresis with amperometric detection.  |  Pan, YL., et al. 2013. Electrophoresis. 34: 1241-8. PMID: 23401052
  7. Effects of chlordimeform and its metabolite 4-chloro-o-toluidine on rat splenic T, B and tumoricidal effector cells.  |  Thomas, WD., et al. 1990. Immunopharmacology. 19: 79-86. PMID: 2351536
  8. En Route to 2-(Cyclobuten-1-yl)-3-(trifluoromethyl)-1H-indole.  |  Gazvoda, M., et al. 2018. J Org Chem. 83: 2486-2493. PMID: 29378397
  9. Carcinomas of the urinary bladder in a 4-chloro-o-toluidine cohort.  |  Stasik, MJ. 1988. Int Arch Occup Environ Health. 60: 21-4. PMID: 3350600
  10. Induction of xenobiotic biotransformation by the insecticide chlordimeform, a metabolite 4-chloro-o-toluidine and a structurally related chemical o-toluidine.  |  Leslie, C., et al. 1988. Biochem Pharmacol. 37: 2529-35. PMID: 3390215
  11. Macromolecular binding and metabolism of the carcinogen 4-chloro-2-methylaniline.  |  Hill, DL., et al. 1979. Cancer Res. 39: 2528-31. PMID: 445453
  12. Studies on the mutagenic potential of the pesticide chlordimeforme and its principal metabolites in the mouse heritable translocation assay.  |  Lang, R. and Adler, ID. 1982. Mutat Res. 92: 243-8. PMID: 7088005
  13. Qualitative and quantitative influences of ortho chlorine substituents on the microsomal metabolism of 4-toluidines.  |  Tyrakowska, B., et al. 1993. Drug Metab Dispos. 21: 508-19. PMID: 8100509
  14. Genotoxicity of 4-chloro-o-toluidine in Salmonella typhimurium, human lymphocytes and V79 cells.  |  Göggelmann, W., et al. 1996. Mutat Res. 370: 39-47. PMID: 8830805

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Chloro-2-methylaniline, 10 g

sc-238801
10 g
$71.00