Date published: 2025-9-29

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4-Bromo-2,3,5,6-tetrafluoropyridine (CAS 3511-90-8)

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CAS Number:
3511-90-8
Molecular Weight:
229.96
Molecular Formula:
C5BrF4N
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Bromo-2,3,5,6-tetrafluoropyridine, referred to as 4-BTP, is an organically halogenated compound that finds extensive use in scientific research. Its versatility allows for a wide range of applications in various fields. In the realm of medicinal chemistry, 4-Bromo-2,3,5,6-tetrafluoropyridine serves as a fundamental building block for synthesizing active compounds. Likewise, materials science benefits from the properties of 4-Bromo-2,3,5,6-tetrafluoropyridine, using it as a building block in the synthesis of various materials such as polymers, organic semiconductors, and organic photovoltaics. Despite its numerous applications, the exact mechanism of action of 4-Bromo-2,3,5,6-tetrafluoropyridine remains somewhat enigmatic. Although researchers have not fully comprehended how it operates, they hypothesize that 4-Bromo-2,3,5,6-tetrafluoropyridine interacts with biological targets through several mechanisms, including hydrogen bonding, electrostatic interactions, and covalent binding. Moreover, it may engage with proteins through non-covalent interactions like van der Waals forces and hydrophobic interactions. 4-Bromo-2,3,5,6-tetrafluoropyridine, with its unique structural features, plays an integral role in scientific endeavors, offering a wealth of opportunities for advancements in diverse fields while also presenting intriguing challenges for researchers to unravel its full potential and mechanisms of action.


4-Bromo-2,3,5,6-tetrafluoropyridine (CAS 3511-90-8) References

  1. Comparative thermodynamic properties, vibrational spectral studies, NBO and HOMO-LUMO analyses of 3-chloro-2,4,5,6-tetrafluoropyridine and 4-bromo-2,3,5,6-tetrafluoropyridine based on density functional theory.  |  Selvarani, C., et al. 2014. Spectrochim Acta A Mol Biomol Spectrosc. 132: 110-20. PMID: 24858352
  2. Synthetic utility of 4-bromo-2,3,5,6-tetrafluoropyridine  |  John A. Christopher a, Laura Brophy a, Sean M. Lynn a, David D. Miller a, Lisa A. Sloan a, Graham Sandford b. 2008. Journal of Fluorine Chemistry. 129: 447-454.
  3. Octafluoro-4, 4′-bipyridine and its derivatives: Synthesis, molecular and crystal structure  |  Alexey V. Gutov, Eduard B. Rusanov, Alexey B. Ryabitskii, Alexander N. Chernega. 2010. Journal of Fluorine Chemistry. 131: 278-281.
  4. Experimental Study of the Reaction of a Ni(PEt3)2 Synthon with Polyfluorinated Pyridines: Concerted, Phosphine-Assisted, or Radical C–F Bond Activation Mechanisms?  |  Jillian A. Hatnean and Samuel A. Johnson*. 2012. Organometallics. 31: 1361–1373.
  5. Resonance enhanced multiphoton ionization − time of flight (REMPI-TOF) detection of Br (2Pj) atoms in the photodissociation of 4-bromo-2,3,5,6-tetrafluoropyridine at 234 nm: Effect of low-lying πσ* states  |  D. Srinivas a, Y. Sajeev b, Hari P. Upadhyaya a. 2017. Journal of Photochemistry and Photobiology A: Chemistry. 345: 1-10.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Bromo-2,3,5,6-tetrafluoropyridine, 1 g

sc-256700
1 g
$43.00