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4-Amino-5-(bromomethyl)-2-methylpyrimidine dihydrobromide (CAS 5423-98-3)

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Application:
4-Amino-5-(bromomethyl)-2-methylpyrimidine dihydrobromide is a pyrimidine derivative of G protein-coupled receptor kinase (GRK) inhibitor
CAS Number:
5423-98-3
Purity:
≥95%
Molecular Weight:
363.88
Molecular Formula:
C6H8BrN32HBr
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-Amino-5-(bromomethyl)-2-methylpyrimidine dihydrobromide is a compound utilized in chemical research, particularly within the context of heterocyclic chemistry. It is studied for its potential as an intermediate in the synthesis of more complex pyrimidine derivatives. The presence of both an amino group and a bromomethyl group on the pyrimidine ring provides reactive sites that are useful in various chemical transformations, such as nucleophilic substitutions or cross-coupling reactions. As a result, this compound is of interest in the design of novel organic molecules with potential applications in materials science and catalysis. Additionally, the hydrobromide salt form enhances the solubility of the compound in polar solvents, which is beneficial for reaction kinetics and process studies.


4-Amino-5-(bromomethyl)-2-methylpyrimidine dihydrobromide (CAS 5423-98-3) References

  1. Aurora A and NF-κB Survival Pathway Drive Chemoresistance in Acute Myeloid Leukemia via the TRAF-Interacting Protein TIFA.  |  Wei, TW., et al. 2017. Cancer Res. 77: 494-508. PMID: 28069801

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-Amino-5-(bromomethyl)-2-methylpyrimidine dihydrobromide, 50 mg

sc-206817
50 mg
$347.00

For 4-Amino-5-(bromomethyl)-2-methylpyrimidine dihydrobromide (CAS 5423-98-3), reported as a GRK (Gprot kinase) inhibitor, could you please indicate a refernce that efectively refers to that compund used as GRK inhibit and any alternative names it has?

Asked by: Juan G
Thank you for your question. We were not able to find any literature reference using this compound as a GRK inhibitor, however we do have a literature reference for the preparation of the product which references it as a GRK inhibitor. Please see the reference below. Preparation of pyrimidine derivatives as G protem-coupled receptor kinase (GRK) inhibitors Fukumoto, ShOJI, Watanabe, Toshifumi, Ikeda, Shota (Takeda Chem1callndustnes, Ltd, Japan) PCT lnt Appl (2002), 322 pp
Answered by: Technical Support
Date published: 2021-03-09
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Rated 5 out of 5 by from It is recommended to make the 4It is recommended to make the 4-Amino-5-(bromomethyl)-2-methylpyrimidine dihydrobromide solution right before use and use it within one day. If you must store this solution, it is recommended to store it at -20 degrees Celsius in aliquots (tightly sealed). It should not be stored for more than a month. -SCBT Publication Review
Date published: 2015-01-19
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4-Amino-5-(bromomethyl)-2-methylpyrimidine dihydrobromide is rated 5.0 out of 5 by 1.
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