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4-(4-Chlorophenyl)-4-hydroxypiperidine (CAS 39512-49-7)

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Alternate Names:
4-(4-Chlorophenyl)-4-hydroxypiperidine
CAS Number:
39512-49-7
Molecular Weight:
211.69
Molecular Formula:
C11H14ClNO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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4-(4-Chlorophenyl)-4-hydroxypiperidine is an organic compound belonging to the piperidine family, characterized by a piperidine ring with a phenyl group bearing a chlorine atom and a hydroxyl group. This compound has found application as useful in exploring the impact of piperidine-based compounds on the nervous system. Furthermore, the potential utilization of 4-(4-Chlorophenyl)-4-hydroxypiperidine in the development of insecticides, herbicides, and fungicides has been the subject of investigation.


4-(4-Chlorophenyl)-4-hydroxypiperidine (CAS 39512-49-7) References

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  2. Synthesis and pharmacological activity of 4-(4'-(chlorophenyl)-4-hydroxypiperidine) derivatives.  |  Saify, ZS., et al. 2005. Chem Pharm Bull (Tokyo). 53: 64-6. PMID: 15635232
  3. Simultaneous analysis of haloperidol, its three metabolites and two other butyrophenone-type neuroleptics by high performance liquid chromatography with dual ultraviolet detection.  |  Higashi, Y., et al. 2006. Biomed Chromatogr. 20: 166-72. PMID: 16034821
  4. Sensitive determination of 4-(4-chlorophenyl)-4-hydroxypiperidine, a metabolite of haloperidol, in a rat biological sample by HPLC with fluorescence detection after pre-column derivatization using 4-fluoro-7-nitro-2,1,3-benzoxadiazole.  |  Higashi, Y., et al. 2006. Biomed Chromatogr. 20: 964-70. PMID: 16506267
  5. [Chemical toxicological analysis of haloperidol metabolite 4-(4-chlorophenyl)-4-hydroxypipiridine in urine by high-performance liquid chromatography].  |  Skorniakova, AB. and Lazarian, DS. 2009. Sud Med Ekspert. 52: 45-8. PMID: 19371012
  6. A high-yield route to synthesize the P-glycoprotein radioligand [11C]N-desmethyl-loperamide and its parent radioligand [11C]loperamide.  |  Wang, M., et al. 2013. Bioorg Med Chem Lett. 23: 5259-63. PMID: 23981899
  7. Synthesis and characterization of [N-methyl-3H]loperamide.  |  Filer, CN., et al. 2014. J Labelled Comp Radiopharm. 57: 437-9. PMID: 24753311
  8. [Ferrocene, ruthenocene and rhodocene analogs in haloperidol synthesis and organ distribution after labeling with 103Ru and 103mRh].  |  Wenzel, M. and Wu, Y. 1988. Int J Rad Appl Instrum A. 39: 1237-41. PMID: 2851003
  9. High-performance liquid chromatographic method for the detection and quantitation of haloperidol and seven of its metabolites in microsomal preparations.  |  Fang, J. and Gorrod, JW. 1993. J Chromatogr. 614: 267-73. PMID: 8314939
  10. Determination of 4-(4-chlorophenyl)-4-hydroxypiperidine, a metabolite of haloperidol, by gas chromatography with electron-capture detection.  |  Fang, J., et al. 1996. J Chromatogr B Biomed Appl. 682: 283-8. PMID: 8844421
  11. Characterization of the cytochrome P450 isoenzymes involved in the in vitro N-dealkylation of haloperidol.  |  Pan, LP., et al. 1997. Br J Clin Pharmacol. 44: 557-64. PMID: 9431831
  12. In-vitro characterization of the cytochrome P450 isoenzymes involved in the back oxidation and N-dealkylation of reduced haloperidol.  |  Pan, LP., et al. 1998. Pharmacogenetics. 8: 383-9. PMID: 9825830

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

4-(4-Chlorophenyl)-4-hydroxypiperidine, 5 g

sc-254564
5 g
$94.00