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Hymeglusin is a fungal beta-lactone cell wall-targeting antibiotic that irreversibly inhibits cytosolic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase by covalently modifying the active Cys 129 residue of the enzyme. Studies show that Hymeglusin can be inhibited by the (2R, 3R)-isomer of beta-lactone trans-DU-6622 because this lactone binds to the same site on HMG-CoA synthase as Hymeglusin. In addition, Hymeglusin suppresses the translation of cWRA in Staphylococcus aureus, which codes for a polypepetide that responds to cell wall inhibition.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
4-(4-Benzyl-1,4-diazepan-1-yl)-4-oxobutanoic acid, 1 g | sc-314482 | 1 g | $263.00 |