4,10-Bis[(1-oxido-2-pyridinyl)methyl]-1,4,7,10-tetraazacyclododecane-1,7-diacetic Acid (CAS 1187176-56-2)

4,10-Bis[(1-oxido-2-pyridinyl)methyl]-1,4,7,10-tetraazacyclododecane-1,7-diacetic acid, commonly referred to as DOTA-BOM, has emerged as a vital compound in various scientific research endeavors, primarily owing to its unique chelating properties and its ability to form stable complexes with metal ions, particularly gadolinium, copper, and lanthanides. The mechanism of action involves the coordination of the central metal ion by the four nitrogen atoms and two oxygen atoms within the DOTA-BOM ligand structure, resulting in the formation of highly stable complexes. These complexes exhibit desirable properties for various applications, including magnetic resonance imaging (MRI) contrast agents, where the gadolinium-DOTA-BOM complex has been extensively studied for its potential as a contrast agent for high-resolution imaging of biological tissues. Additionally, DOTA-BOM complexes have found utility in molecular imaging and nuclear medicine, serving as chelators for radioisotopes used in positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging studies. Furthermore, the versatility of DOTA-BOM in forming complexes with different metal ions makes it a valuable tool in coordination chemistry research, exploring diverse applications ranging from catalysis to materials science.