3(S)-Oxidosqualene (CAS 54910-48-4)
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3(S)-Oxidosqualene is a intermediate in the biosynthesis of various isoprenoids, such as sterols and triterpenoids, making it a component for the synthesis of cholesterol—an essential molecule for proper bodily function. Thus, researchers have extensively studied 3(S)-Oxidosqualene due to its significance in the biosynthesis of these compounds. It is used as a substrate for studying the enzymes involved in isoprenoid biosynthesis, as well as a precursor for synthesizing natural products such as squalene epoxide, which exhibits anti-inflammatory and anti-cancer properties. The conversion of 3(S)-Oxidosqualene to lanosterol marks a significant step in cholesterol biosynthesis, facilitated by the enzyme squalene epoxidase. Subsequently, lanosterol undergoes a series of enzymatic reactions to form cholesterol. Feedback inhibition precisely regulates cholesterol biosynthesis, ensuring the production of an appropriate amount within the body.
3(S)-Oxidosqualene (CAS 54910-48-4) References
- Genome mining to identify new plant triterpenoids. | Fazio, GC., et al. 2004. J Am Chem Soc. 126: 5678-9. PMID: 15125655
- Deletion of the Gly600 residue of Alicyclobacillus acidocaldarius squalene cyclase alters the substrate specificity into that of the eukaryotic-type cyclase specific to (3S)-2,3-oxidosqualene. | Hoshino, T., et al. 2004. Angew Chem Int Ed Engl. 43: 6700-3. PMID: 15593147
- Squalene cyclase and oxidosqualene cyclase from a fern. | Shinozaki, J., et al. 2008. FEBS Lett. 582: 310-8. PMID: 18154734
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3(S)-Oxidosqualene, 2.5 mg | sc-478441 | 2.5 mg | $408.00 | |||
3(S)-Oxidosqualene, 10 mg | sc-478441A | 10 mg | $1428.00 | |||
3(S)-Oxidosqualene, 25 mg | sc-478441B | 25 mg | $3060.00 |