Molecular structure of 3-Methylguanine, CAS Number: 2958-98-7
3-Methylguanine (CAS 2958-98-7)
Alternate Names:
N3-Methylguanine; NSC 62622; 2-Amino-3,7-dihydro-3-methyl-6H-purin-6-one; 3-Methylguanine; 2-Amino-3-methyl-6-oxo-3,6-dihydro-7H-purine
CAS Number:
2958-98-7
Molecular Weight:
165.15
Molecular Formula:
C6H7N5O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
3-Methylguanine is a derivative of the nucleobase guanine and has been investigated as a potential purine antagonist. This compound acts as an inhibitor of glycosylases, which are enzymes responsible for removing methyl groups from DNA and RNA bases. 3-Methylguanine exhibits optimal activity at a neutral pH (pH 7). It can been detected in urine samples.
3-Methylguanine (CAS 2958-98-7) References
- 3-Methyladenine-DNA glycosylase I from Escherichia coli-computer modeling and supporting experimental evidence. | Plochocka, D., et al. 2000. Biochem Biophys Res Commun. 268: 724-7. PMID: 10679272
- Partial purification and characterization of 3-methyladenine-DNA glycosylase from human placenta. | Gallagher, PE. and Brent, TP. 1982. Biochemistry. 21: 6404-9. PMID: 7150564
- Excision of 3-methylguanine from alkylated DNA by 3-methyladenine DNA glycosylase I of Escherichia coli. | Bjelland, S., et al. 1993. Nucleic Acids Res. 21: 2045-9. PMID: 8502545
- Distinct substrate preference of human and mouse N-methylpurine-DNA glycosylases. | Roy, R., et al. 1996. Carcinogenesis. 17: 2177-82. PMID: 8895486
- Activity of Escherichia coli DNA-glycosylases on DNA damaged by methylating and ethylating agents and influence of 3-substituted adenine derivatives. | Tudek, B., et al. 1998. Mutat Res. 407: 169-76. PMID: 9637245
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| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-Methylguanine, 25 mg | sc-483803 | 25 mg | $406.00 |