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3-formylrifamycin SV (CAS 13292-22-3)

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Alternate Names:
3-Formylrifamycin
Application:
3-formylrifamycin SV is a compound that interacts with biological membranes
CAS Number:
13292-22-3
Purity:
≥98%
Molecular Weight:
725.78
Molecular Formula:
C38H47NO13
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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3-formylrifamycin SV is a semisynthetic derivative of the rifamycin class that is explored primarily for its chemical properties and potential as a starting material for further chemical modifications. In synthetic organic chemistry, it serves as a key intermediate in the preparation of various rifamycin analogs. The formyl group present in the compound provides a reactive site for modifications, enabling researchers to study structure-activity relationships by synthesizing new derivatives with potential applications. Its role in chemical reactions, such as condensation to form Schiff bases or reduction to form alcohol derivatives, is of particular interest. Additionally, 3-formylrifamycin SV is used in studies aimed at understanding the mechanisms of action of rifamycin compounds at a molecular level. Research involving this compound also includes the exploration of its interactions with biological molecules, which can lead to insights into the modulation of biological pathways.


3-formylrifamycin SV (CAS 13292-22-3) References

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  2. Polymer-supported (2,6-dichloro- 4-alkoxyphenyl)(2,4-dichlorophenyl)methanol: a new linker for solid-phase organic synthesis.  |  Kurosu, M., et al. 2007. Org Lett. 9: 1141-4. PMID: 17311394
  3. HPLC determination of rifampicin and related compounds in pharmaceuticals using monolithic column.  |  Liu, J., et al. 2008. J Pharm Biomed Anal. 46: 405-9. PMID: 18055155
  4. The behavior of PLGA microspheres containing rifampicin in alveolar macrophages.  |  Onoshita, T., et al. 2010. Colloids Surf B Biointerfaces. 76: 151-7. PMID: 19954935
  5. Lessons from seven decades of antituberculosis drug discovery.  |  Barry, CE. 2011. Curr Top Med Chem. 11: 1216-25. PMID: 21401509
  6. 13C and 15N CP/MAS, 1H-15N SCT CP/MAS and FTIR spectroscopy as tools for qualitative detection of the presence of zwitterionic and non-ionic forms of ansa-macrolide 3-formylrifamycin SV and its derivatives in solid state.  |  Przybylski, P., et al. 2014. Magn Reson Chem. 52: 10-21. PMID: 24347399
  7. Structure and evaluation of antibacterial and antitubercular properties of new basic and heterocyclic 3-formylrifamycin SV derivatives obtained via 'click chemistry' approach.  |  Pyta, K., et al. 2014. Eur J Med Chem. 84: 651-76. PMID: 25063947
  8. Pharmaceutical Development of Nanostructured Vesicular Hydrogel Formulations of Rifampicin for Wound Healing.  |  Wallenwein, CM., et al. 2022. Int J Mol Sci. 23: PMID: 36555855
  9. Development and Characterization of Pharmaceutical Systems Containing Rifampicin.  |  Dan Córdoba, AV., et al. 2023. Pharmaceutics. 15: PMID: 36678827
  10. The reaction of 3-formylrifamycin SV with sulphonium and phosphonium ylides.  |  Cricchio, R., et al. 1974. Farmaco Sci. 29: 358-65. PMID: 4838292
  11. High-pressure liquid chromatographic quantitation of rifampin and its two major metabolites in urine and serum.  |  Weber, A., et al. 1983. Rev Infect Dis. 5 Suppl 3: S433-9. PMID: 6635434
  12. Inactivated products of rifampicin by pathogenic Nocardia spp.: structures of glycosylated and phosphorylated metabolites of rifampicin and 3-formylrifamycin SV.  |  Morisaki, N., et al. 1993. J Antibiot (Tokyo). 46: 1605-10. PMID: 8244890
  13. Effect of rifampicin derivatives on the ion compartmentation of biological membranes.  |  Inouye, B., et al. 1977. J Antibiot (Tokyo). 30: 494-9. PMID: 885810

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3-formylrifamycin SV, 1 g

sc-204879
1 g
$123.00

3-formylrifamycin SV, 5 g

sc-204879A
5 g
$462.00