Date published: 2025-12-8

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3-(4-Fluorobenzoyl)propionic acid (CAS 366-77-8)

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Application:
3-(4-Fluorobenzoyl)propionic acid is a metabolite of haloperidol
CAS Number:
366-77-8
Molecular Weight:
196.18
Molecular Formula:
C10H9FO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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3-(4-Fluorobenzoyl)propionic acid is a metabolite of haloperidol. 3-(4-Fluorobenzoyl)propionic acid, known as 4-FBP, represents an organic compound characterized by a benzene ring that hosts a carboxylic acid group positioned at the 3-spot, accompanied by a fluorine atom situated at the 4-position. It adopts the form of a transparent solid with the ability to dissolve in organic solvents like ethanol and methanol. This compound, 3-(4-Fluorobenzoyl)propionic acid, possesses remarkable versatility and finds application across a diverse spectrum, including biochemistry investigations and chemical analyses. Within the realm of scientific research, 3-(4-Fluorobenzoyl)propionic acid finds itself harnessed in a multitude of roles. In the field of biochemistry, 3-(4-Fluorobenzoyl)propionic acid facilitates explorations into the intricate structures and functions of proteins, DNA, and other vital biomolecules. Its significance extends to chemical analysis, where it serves as a pivotal reagent enabling the detection and precise quantification of a wide array of compounds. Operating as a proton acceptor, 3-(4-Fluorobenzoyl)propionic acid exhibits the capability to furnish a proton to electron-deficient entities, particularly carbonyl groups.


3-(4-Fluorobenzoyl)propionic acid (CAS 366-77-8) References

  1. p-Fluorophenylglycine in the urine of baboons treated with HPTP, the tetrahydropyridine analog of haloperidol.  |  Mienie, LJ., et al. 1999. Life Sci. 65: 535-42. PMID: 10462080
  2. Synthesis and central nervous system depressant activity of some bicyclic amides.  |  Aeberli, P., et al. 1976. J Med Chem. 19: 436-8. PMID: 1255670
  3. Simultaneous analysis of haloperidol, its three metabolites and two other butyrophenone-type neuroleptics by high performance liquid chromatography with dual ultraviolet detection.  |  Higashi, Y., et al. 2006. Biomed Chromatogr. 20: 166-72. PMID: 16034821
  4. Identification of a new functional target of haloperidol metabolite: implications for a receptor-independent role of 3-(4-fluorobenzoyl) propionic acid.  |  Kim, HS., et al. 2006. J Neurochem. 99: 458-69. PMID: 17029599
  5. Haloperidol regulates the phosphorylation level of the MEK-ERK-p90RSK signal pathway via protein phosphatase 2A in the rat frontal cortex.  |  Kim, SH., et al. 2008. Int J Neuropsychopharmacol. 11: 509-17. PMID: 18272021
  6. [Chemical toxicological analysis of haloperidol metabolite 4-(4-chlorophenyl)-4-hydroxypipiridine in urine by high-performance liquid chromatography].  |  Skorniakova, AB. and Lazarian, DS. 2009. Sud Med Ekspert. 52: 45-8. PMID: 19371012
  7. Metabolites of haloperidol display preferential activity at sigma receptors compared to dopamine D-2 receptors.  |  Bowen, WD., et al. 1990. Eur J Pharmacol. 177: 111-8. PMID: 2155804
  8. Multi-receptor drug design: Haloperidol as a scaffold for the design and synthesis of atypical antipsychotic agents.  |  Peprah, K., et al. 2012. Bioorg Med Chem. 20: 1291-7. PMID: 22245230
  9. An ex Vivo Model for Evaluating Blood-Brain Barrier Permeability, Efflux, and Drug Metabolism.  |  Hellman, K., et al. 2016. ACS Chem Neurosci. 7: 668-80. PMID: 26930271
  10. In vivo assessment of neurotransmitter biochemistry in humans.  |  Barrio, JR., et al. 1988. Annu Rev Pharmacol Toxicol. 28: 213-30. PMID: 2898234
  11. Identification and quantification of diphenhydramine, haloperidol, and its metabolite, reduced haloperidol in a saponified brain specimen that was immersed in the sea water for more than 10 years.  |  Natori, Y., et al. 2023. Leg Med (Tokyo). 61: 102188. PMID: 36603491
  12. A direct comparison of the brain uptake and plasma clearance of N-[11C]methylspiroperidol and [18F]N-methylspiroperidol in baboon using PET.  |  Fowler, JS., et al. 1986. Int J Rad Appl Instrum B. 13: 281-4. PMID: 3771261
  13. Antihypertensive agents: angiotensin converting enzyme inhibitors. 1-[3-(Acylthio)-3-aroylpropionyl]-L-prolines.  |  McEvoy, FJ., et al. 1983. J Med Chem. 26: 381-93. PMID: 6298428

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3-(4-Fluorobenzoyl)propionic acid, 5 g

sc-231328
5 g
$18.00