Date published: 2025-10-14

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3,4-Dihydroxybenzaldehyde (CAS 139-85-5)

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Alternate Names:
Protocatechuic aldehyde
Application:
3,4-Dihydroxybenzaldehyde is an apoptosis inducer of human leukemia cells
CAS Number:
139-85-5
Purity:
≥98%
Molecular Weight:
138.12
Molecular Formula:
C7H6O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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3,4-Dihydroxybenzaldehyde is a naturally occurring chemical compound found in various plants and animals. 3,4-Dihydroxybenzaldehyde is classified as an aromatic aldehyde, characterized by a benzene ring with a formyl group attached. In vitro studies have highlighted its effectiveness in inhibiting the growth of bacteria and fungi. Although the exact mechanism of action of 3,4-Dihydroxybenzaldehyde remains partially understood, it is believed to exert its effects by inhibiting enzymes involved in lipid, protein, and carbohydrate metabolism.


3,4-Dihydroxybenzaldehyde (CAS 139-85-5) References

  1. Mechanistic study of electrochemical oxidation of 2,5-dihydroxybenzoic acid and 3,4-dihydroxybenzaldehyde in the presence of 3-hydroxy-1H-phenalene-1-one.  |  Nematollahi, D. and Amani, A. 2008. Chem Pharm Bull (Tokyo). 56: 513-7. PMID: 18379100
  2. 3,4-dihydroxybenzaldehyde purified from the barley seeds (Hordeum vulgare) inhibits oxidative DNA damage and apoptosis via its antioxidant activity.  |  Jeong, JB., et al. 2009. Phytomedicine. 16: 85-94. PMID: 19022639
  3. Apoptotic cell death through inhibition of protein kinase CKII activity by 3,4-dihydroxybenzaldehyde purified from Xanthium strumarium.  |  Lee, BH., et al. 2008. Nat Prod Res. 22: 1441-50. PMID: 19023807
  4. 3,4-Dihydroxybenzaldehyde Derived from Prunus mume Seed Inhibits Oxidative Stress and Enhances Estradiol Secretion in Human Ovarian Granulosa Tumor Cells.  |  Kono, R., et al. 2014. Acta Histochem Cytochem. 47: 103-12. PMID: 25320407
  5. A chemical model of catechol-O-methyltransferase. Methylation of 3,4-dihydroxybenzaldehyde in aqueous solution.  |  Sugata, S., et al. 1989. Chem Pharm Bull (Tokyo). 37: 1143-6. PMID: 2630085
  6. 3,4-Dihydroxybenzaldehyde quenches ROS and RNS and protects human blood cells from Cr(VI)-induced cytotoxicity and genotoxicity.  |  Husain, N. and Mahmood, R. 2018. Toxicol In Vitro. 50: 293-304. PMID: 29665407
  7. Anti-corrosion and microstructural properties of Ni-W alloy coatings: effect of 3,4-Dihydroxybenzaldehyde.  |  Pramod Kumar, U., et al. 2019. Heliyon. 5: e01288. PMID: 30899827
  8. Anti-neuroinflammatory effect of 3,4-dihydroxybenzaldehyde in ischemic stroke.  |  Li, X., et al. 2020. Int Immunopharmacol. 82: 106353. PMID: 32143007
  9. 3,4-Dihydroxybenzaldehyde attenuates pentachlorophenol-induced cytotoxicity, DNA damage and collapse of mitochondrial membrane potential in isolated human blood cells.  |  Maheshwari, N. and Mahmood, R. 2022. Drug Chem Toxicol. 45: 1225-1242. PMID: 32854525
  10. Cross-Linking Porcine Pericardium by 3,4-Dihydroxybenzaldehyde: A Novel Method to Improve the Biocompatibility of Bioprosthetic Valve.  |  Wu, B., et al. 2021. Biomacromolecules. 22: 823-836. PMID: 33375781
  11. 3,4-Dihydroxybenzaldehyde mitigates fluoride-induced cytotoxicity and oxidative damage in human RBC.  |  Anjum, R., et al. 2022. J Trace Elem Med Biol. 69: 126888. PMID: 34773916
  12. Anti-Allergic Effect of 3,4-Dihydroxybenzaldehyde Isolated from Polysiphonia morrowii in IgE/BSA-Stimulated Mast Cells and a Passive Cutaneous Anaphylaxis Mouse Model.  |  Kim, EA., et al. 2022. Mar Drugs. 20: PMID: 35200662
  13. Metabolomic analysis and pharmacological validation of the cerebral protective effect of 3,4‑dihydroxybenzaldehyde on cerebral ischemia‑reperfusion injury.  |  Luo, Y., et al. 2023. Mol Med Rep. 27: PMID: 36367170

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3,4-Dihydroxybenzaldehyde, 25 g

sc-216575
25 g
$108.00