![3-[2-(4-Fluorophenoxy)ethyl]piperidine - chemical structure image](https://media.scbt.com/product/3-2-4-fluorophenoxy-ethylpiperidine-structure_22_69_b_226948.jpg)
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2-APB is a transient receptor potential (TRP) activator. The compound also directly blocks the mitochondrial permeability transition pore, sarco/endoplasmic reticulum Ca2+-ATPase pumps, and native store operated channels, as well as other ion channels. 2-APB does not activate the subfamily transient receptor potential vanilloids (TRPVs) TRPV4, TRPV5, and TRPV6, but can activate VR1 (TRPV1), VRL-1 (TRPV2), and TRPV3. 2-ABP was first used as an inhibitor of IP3R (inositol 1,4,5-triphosphate receptor) with the ability to permeate the membrane. 2-ABP can induce Ca2+entry without activating exocytosis. In pancreatic acinar cells 2-ABP can inhibit calcium mobilization. 2-APB is an activator of Orai3.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-[2-(4-Fluorophenoxy)ethyl]piperidine, 500 mg | sc-310653 | 500 mg | $294.00 |