3-(1,2,4-Triazol-1-yl)-L-alanine (CAS 4819-36-7)

3-(1,2,4-Triazol-1-yl)-L-alanine is a compound of interest in the field of chemical biology and organic chemistry due to its unique incorporation of a triazole moiety. As a modified amino acid, it is used to study peptide structure-function relationships, providing insights into the role of unconventional amino acids in peptide chains. The triazole ring, a heterocyclic structure, is known for its mimicry of peptide bonds and is thus leveraged in peptidomimetics research, exploring its stability and resistance to enzymatic degradation. Additionally, 3-(1,2,4-Triazol-1-yl)-L-alanine serves as a building block in the synthesis of novel peptides and proteins with potential altered properties or functions. Its application extends to the design of enzyme inhibitors, where the introduction of a triazole group can enhance binding affinity and specificity. Researchers also employ this compound to investigate the effects of non-canonical amino acids on the biosynthesis and folding of proteins.