(2S,5S)-(−)-2-tert-Butyl-3-methyl-5-benzyl-4-imidazolidinone (CAS 346440-54-8)

(2S,5S)-(−)-2-tert-Butyl-3-methyl-5-benzyl-4-imidazolidinone, known as 2S,5S-tBMBZI, is a chiral imidazolidinone with various applications in organic synthesis. This compound serves as a valuable chiral auxiliary in asymmetric synthesis and finds versatile use as a building block for creating diverse compounds. In scientific research, (2S,5S)-(−)-2-tert-Butyl-3-methyl-5-benzyl-4-imidazolidinone has demonstrated its efficacy in several areas. It has proven beneficial in asymmetric synthesis, enabling the synthesis of amino acids, peptides, and nucleosides, each with specific chirality. Its utility extends to enantioselective catalysis, where it acts as a chiral ligand, creating an ideal chiral environment for the reaction process. The mechanism of action of (2S,5S)-(−)-2-tert-Butyl-3-methyl-5-benzyl-4-imidazolidinone depends on its particular application. As a chiral auxiliary in asymmetric synthesis, it aids in the creation of new stereogenic centers. In enantioselective catalysis, it functions as a chiral ligand, fostering the reaction′s enantioselectivity. Similarly, in dynamic kinetic resolutions, it acts as a chiral auxiliary, assisting in generating new stereogenic centers.