2′,3′-Dideoxy-3′-fluorouridine (CAS 41107-56-6)

2′,3′-Dideoxy-3′-fluorouridine, a synthetic nucleoside analogue, has gained attention in scientific research due to its unique mechanisms of action and potential applications in various fields. This chemical interferes with nucleic acid synthesis by acting as a chain terminator during RNA transcription. Specifically, it replaces the 3′-hydroxyl group of the ribose sugar with a fluorine atom, preventing the addition of subsequent nucleotides and halting RNA elongation. This mechanism makes it particularly valuable in molecular biology and virology research, where it is used to study RNA-dependent processes such as viral replication and transcription. Researchers have utilized 2′,3′-dideoxy-3′-fluorouridine to investigate the replication mechanisms of RNA viruses, including HIV and hepatitis C virus (HCV), providing insights into the development of antiviral therapies targeting viral RNA synthesis. Additionally, this compound has been employed in structural biology to study RNA-protein interactions and RNA folding kinetics, elucidating the molecular basis of RNA function and regulation. Furthermore, its potential as an agent for viral infections has prompted investigations into novel drug delivery systems and pharmacokinetic profiles to enhance its efficacy and bioavailability. Overall, 2′,3′-dideoxy-3′-fluorouridine′s unique mechanism of action and diverse research applications highlight its significance as a valuable tool for understanding RNA biology, viral pathogenesis, and drug development.