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25-O-Deacetyl Rifabutin (CAS 100324-63-8)

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Alternate Names:
25-Hydroxy Rifabutin; 25-O-Deacetylrifabutin; 25-O-Desacetylrifabutin
Application:
25-O-Deacetyl Rifabutin is a metabolite of Rifabutin which exhibits antibacterial properties.
CAS Number:
100324-63-8
Molecular Weight:
804.97
Molecular Formula:
C44H60N4O10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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25-O-Deacetyl Rifabutin (25-O-DAR) is a semisynthetic analog of rifabutin and serves to enhance the bioavailability of its parent compound. In scientific studies, this compound is utilized to investigate the underlying mechanisms by which rifabutin operates, particularly its interaction with the cell wall synthesis of Mycobacterium tuberculosis. 25-O-Deacetyl Rifabutin has been instrumental in examining the bacterium responsible for tuberculosis and exploring rifabutin′s potential broader applications. Research involving this chemical also delves into its pharmacokinetic properties and its exploration as an anti-inflammatory agent. Regarding its physiological mechanism, 25-O-Deacetyl Rifabutin is converted into rifabutin, which acts by blocking the production of mycolic acids, constituents of the bacterium′s cell wall, leading to its elimination.


25-O-Deacetyl Rifabutin (CAS 100324-63-8) References

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  7. In vivo disposition and metabolism by liver and enterocyte microsomes of the antitubercular drug rifabutin in rats.  |  Koudriakova, T., et al. 1996. J Pharmacol Exp Ther. 279: 1300-9. PMID: 8968354
  8. A model based assessment of redistribution dependent elimination and bioavailability of rifabutin.  |  Li, RC., et al. 1996. Biopharm Drug Dispos. 17: 223-36. PMID: 8983397
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

25-O-Deacetyl Rifabutin, 10 mg

sc-209399
10 mg
$332.00