Date published: 2025-12-5

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2-Phenylbutyramide (CAS 90-26-6)

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Alternate Names:
α-Phenyl-α-ethylacetamide; (±)-2-Phenylbutyramide; 2-Phenylbutanamide
CAS Number:
90-26-6
Molecular Weight:
163.22
Molecular Formula:
C10H13NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Phenylbutyramide is explored in organic chemistry for its role as an intermediate in the synthesis of various organic molecules. It is particularly for its participation in studies related to the structure-activity relationship (SAR) of bioactive compounds, where modifications to the phenyl or butyramide moieties can lead to insights into the interaction between small molecules and biological targets. In materials science, 2-Phenylbutyramide′s ability to engage in hydrogen bonding makes it an interesting candidate for the creation of supramolecular structures, which have implications in the development of novel polymers or gelators. 2-Phenylbutyramide′s structural characteristics are utilized in the field of catalysis, where investigation of its potential as a ligand or organocatalyst that can influence reaction selectivity and rates. Its applications that are looking into extend to probing the fundamental principles of molecular recognition and assembly, which are for the advancement of chemical synthesis and material design.


2-Phenylbutyramide (CAS 90-26-6) References

  1. Anticonvulsants Based on the α-Substituted Amide Group Pharmacophore Bind to and Inhibit Function of Neuronal Nicotinic Acetylcholine Receptors.  |  Krivoshein, AV. 2016. ACS Chem Neurosci. 7: 316-26. PMID: 26741746
  2. Absolute Configuration and Polymorphism of 2-Phenylbutyramide and α-Methyl-α-phenylsuccinimide.  |  Khrustalev, VN., et al. 2014. Cryst Growth Des. 14: 3360-3369. PMID: 27182205
  3. α-Substituted Lactams and Acetamides: Ion Channel Modulators that Show Promise in Treating Drug-resistant Epilepsy.  |  Krivoshein, AV. 2020. Cent Nerv Syst Agents Med Chem. 20: 79-87. PMID: 32386500
  4. The effect of phenobarbital treatment on behavioral comorbidities and on the composition and function of the fecal microbiome in dogs with idiopathic epilepsy.  |  Watanangura, A., et al. 2022. Front Vet Sci. 9: 933905. PMID: 35990279
  5. Acylureas: a new class of barbiturate-like bacterial cytochrome P-450 inducers.  |  Ruettinger, RT., et al. 1984. Biochim Biophys Acta. 801: 372-80. PMID: 6435683

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Phenylbutyramide, 100 g

sc-275143
100 g
$203.00