2-Phenyl-2-(1-piperidinyl)propane CAS: 92321-29-4
MF: C14H21N
MW: 203.32
An enzyme inhibitor and a selective inactivator of CYP2B6.

2-Phenyl-2-(1-piperidinyl)propane (CAS 92321-29-4)

2-Phenyl-2-(1-piperidinyl)propane | CAS 92321-29-4 is rated 5.0 out of 5 by 1.
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Alternate Names: 1-(1-Methyl-1-phenylethyl)piperidine
Application: 2-Phenyl-2-(1-piperidinyl)propane is an enzyme inhibitor and a selective inactivator of CYP2B6
CAS Number: 92321-29-4
Molecular Weight: 203.32
Molecular Formula: C14H21N
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

2-Phenyl-2-(1-piperidinyl)propane, an enzyme inhibitor and a selective inactivator of CYP2B6.


References

1. Welch, R M., et al., 1987. Pharmacological significance of the species differences in bupropion metabolism. Xenobiotica; the fate of foreign compounds in biological systems. 17(3): 287-98. PMID: 3107223
2. Bjornsson, Thorir D., et al., 2003. The conduct of in vitro and in vivo drug-drug interaction studies: a Pharmaceutical Research and Manufacturers of America (PhRMA) perspective. Drug metabolism and disposition: the biological fate of chemicals. 31(7): 815-32. PMID: 12814957
3. Harleton, Erin., et al., 2004. Metabolism of N,N',N"-triethylenethiophosphoramide by CYP2B1 and CYP2B6 results in the inactivation of both isoforms by two distinct mechanisms. The Journal of pharmacology and experimental therapeutics. 310(3): 1011-9. PMID: 15121764
4. Turpeinen, Miia., et al., 2005. Effect of clopidogrel and ticlopidine on cytochrome P450 2B6 activity as measured by bupropion hydroxylation. Clinical pharmacology and therapeutics. 77(6): 553-9. PMID: 15961986

Appearance :
Oil
Physical State :
Liquid
Solubility :
Soluble in chloroform, and ethyl acetate.
Storage :
Store at 4° C
Boiling Point :
~271.1° C at 760 mmHg (Predicted)
Density :
~1.0 g/mL (Predicted)
Refractive Index :
n20D 1.53 (Predicted)
Ki Data :
CYP2B6: Ki= 1.2 µM (human); Cytochrome P450 2B1: Ki= 12 µM (rat)
pK Values :
pKb: 9.74 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
210768
MDL Number :
MFCD00870884
SMILES :
CC(C)(C1=CC=CC=C1)N2CCCCC2

Download SDS (MSDS)

Certificate of Analysis

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2-Phenyl-2-(1-piperidinyl)propane (CAS 92321-29-4)  Product Citations

See how others have used 2-Phenyl-2-(1-piperidinyl)propane (CAS 92321-29-4). Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 23917319  Lade, JM. et al. 2013. Antimicrob. Agents Chemother. 57: 5067-79.

PMID: # 23965226  To, EE. et al. 2013. Biochem. Pharmacol. 86: 979-90.

PMID: # 22923690  Lu, Y. et al. 2012. Drug Metab. Dispos. 40: 2221-30.

PMID: # 22269145  Yanakakis, LJ. et al. 2012. Drug Metab. Dispos. 40: 803-14.

Citations 1 to 4 of 4 total
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Rated 5 out of 5 by from Walsky RL; et al Walsky RL; et al. (PubMed ID: 17682072) determined that 2-Phenyl-2-(1-piperidinyl)propane is a chemical inactivator of CYP2B6 and can be used to further study the role of CYP2B6 in drug metabolism. -SCBT Publication Review
Date published: 2015-04-10
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