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2-Phenyl-2-(1-piperidinyl)propane (CAS 92321-29-4)

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Alternate Names:
1-(1-Methyl-1-phenylethyl)piperidine
Application:
2-Phenyl-2-(1-piperidinyl)propane is an enzyme inhibitor and a selective inactivator of CYP2B6
CAS Number:
92321-29-4
Molecular Weight:
203.32
Molecular Formula:
C14H21N
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Phenyl-2-(1-piperidinyl)propane serves as a compound used in synthetic organic chemistry research, where it is a building block for the synthesis of various complex organic molecules. Its structure, which features both a phenyl ring and a piperidine moiety, makes it a candidate for constructing ligands that can bind to an array of biological targets in mechanistic studies. The compound is particularly interesting to researchers investigating the properties of organic compounds that contain both aromatic and aliphatic nitrogen components, considering their potential to engage in pi-stacking and hydrogen bonding interactions. It is also utilized in the exploration of chemical space in the design of new compounds with potential interactions with enzymes and other proteins. Additionally, 2-Phenyl-2-(1-piperidinyl)propane is involved in catalysis research, where researchers examine its role as a potential intermediate in catalytic cycles or as a ligand that could influence the outcome of chemical reactions.


2-Phenyl-2-(1-piperidinyl)propane (CAS 92321-29-4) References

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  2. The conduct of in vitro and in vivo drug-drug interaction studies: a Pharmaceutical Research and Manufacturers of America (PhRMA) perspective.  |  Bjornsson, TD., et al. 2003. Drug Metab Dispos. 31: 815-32. PMID: 12814957
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  4. Effect of clopidogrel and ticlopidine on cytochrome P450 2B6 activity as measured by bupropion hydroxylation.  |  Turpeinen, M., et al. 2005. Clin Pharmacol Ther. 77: 553-9. PMID: 15961986
  5. Evaluation of 227 drugs for in vitro inhibition of cytochrome P450 2B6.  |  Walsky, RL., et al. 2006. J Clin Pharmacol. 46: 1426-38. PMID: 17101742
  6. New potent and selective cytochrome P450 2B6 (CYP2B6) inhibitors based on three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis.  |  Korhonen, LE., et al. 2007. Br J Pharmacol. 150: 932-42. PMID: 17325652
  7. A comparison of 2-phenyl-2-(1-piperidinyl)propane (ppp), 1,1',1''-phosphinothioylidynetrisaziridine (thioTEPA), clopidogrel, and ticlopidine as selective inactivators of human cytochrome P450 2B6.  |  Walsky, RL. and Obach, RS. 2007. Drug Metab Dispos. 35: 2053-9. PMID: 17682072
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Phenyl-2-(1-piperidinyl)propane, 5 mg

sc-206481
5 mg
$153.00

2-Phenyl-2-(1-piperidinyl)propane, 25 mg

sc-206481A
25 mg
$551.00

2-Phenyl-2-(1-piperidinyl)propane, 100 mg

sc-206481B
100 mg
$959.00

2-Phenyl-2-(1-piperidinyl)propane, 250 mg

sc-206481C
250 mg
$1533.00