2-Phenyl-1,3-indandione (CAS 83-12-5)

2-Phenyl-1,3-indandione, also known as phenylindanedione or PID, belongs to the class of organic compounds called indanediones. Indanediones are compounds containing an indane ring bearing two ketone groups. This medication works by inhibiting the reduction of vitamin K1 epoxide to vitamin K1, specifically by interfering with vitamin K1 epoxide reductase in rat liver homogenates. Its inhibitory effect is concentration-dependentIn vivo studies have shown that when administered at a dosage of 500 mg/kg, phenindione inhibits prothrombin synthesis by 50% and reduces the conversion of vitamin K1 epoxide to vitamin K1 by 57% in rats. In terms of its physical properties, 2-Phenyl-1,3-indandione is a solid substance that is practically insoluble in water and is relatively neutral. 2-Phenyl-1,3-indandione is a potentially toxic compound. While it shares similarities with warfarin in its anticoagulant actions, it has fallen out of favor due to a higher incidence of severe adverse effects, as documented in Martindale, The Extra Pharmacopoeia, 30th ed, page 234.