2-Morpholinoethyl isocyanide (CAS 78375-48-1)
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2-Morpholinoethyl isocyanide is a compound of interest in synthetic organic chemistry, particularly in the context of isocyanide-based multicomponent reactions (MCRs). Its morpholino ring provides both steric bulk and an electron-donating effect, which can influence the reactivity and selectivity of the isocyanide group in these reactions. Researchers explore its use in the Ugi reaction, where it can be combined with aldehydes, amines, and carboxylic acids to synthesize a diverse array of products including peptidomimetics, heterocycles, and other complex organic molecules. The morpholino moiety is also recognized for its potential to impart solubility in polar solvents, which is advantageous during reaction optimization and product isolation. Studies involving 2-Morpholinoethyl isocyanide aim to uncover new catalytic systems and reaction conditions that can enhance the efficiency and scope of MCRs. In addition, this compound′s utility in constructing pharmacophore models is examined, as the products derived from such isocyanides can resemble biologically active structures and thus are relevant for the synthesis of small-molecule libraries for high-throughput screening.
2-Morpholinoethyl isocyanide (CAS 78375-48-1) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Morpholinoethyl isocyanide, 10 ml | sc-251788 | 10 ml | $158.00 |