Date published: 2026-1-16

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2-(Methylthio)-1,4,5,6-tetrahydropyrimidine hydroiodide (CAS 5445-73-8)

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Alternate Names:
2-(Methylsulfanyl)-1,4,5,6-tetrahydropyrimidine hydroiodide; 2-(Methylmercapto)-1,4,5,6-tetrahydropyrimidine hydroiodide
CAS Number:
5445-73-8
Molecular Weight:
258.12
Molecular Formula:
C5H10N2S•HI
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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The primary research application of 2-(Methylthio)-1,4,5,6-tetrahydropyrimidine hydroiodide lies in its role as a synthetic intermediate. The compound′s reactivity, especially due to the presence of the methylthio group and the tetrahydropyrimidine core, makes it a valuable building block in the construction of more complex molecules. Researchers are interested in exploring its use in creating agrochemicals, and novel organic compounds. The ability to introduce a sulfur atom into target molecules can be particularly useful in pharmaceutical chemistry, where sulfur-containing compounds often exhibit significant biological activity. Another potential application area for this compound is in catalysis. The specific structure of 2-(Methylthio)-1,4,5,6-tetrahydropyrimidine hydroiodide may offer unique catalytic properties, especially in reactions where the transfer of sulfur or the activation of pyrimidine rings is beneficial. Studies may focus on its use as a catalyst or cocatalyst in promoting certain types of chemical reactions, such as those involving the formation or breaking of carbon-sulfur bonds. In material science, researchers might explore the incorporation of 2-(Methylthio)-1,4,5,6-tetrahydropyrimidine hydroiodide into polymers or other materials to impart specific characteristics, such as enhanced conductivity or stability. The interaction of the sulfur-containing moiety with other elements in a material matrix could lead to the development of materials with novel properties, useful in electronics, coatings, or as functional additives.


2-(Methylthio)-1,4,5,6-tetrahydropyrimidine hydroiodide (CAS 5445-73-8) References

  1. Identification of non-peptidic neuromedin U receptor modulators by a robust homogeneous screening assay.  |  Meng, T., et al. 2008. Acta Pharmacol Sin. 29: 517-27. PMID: 18358099
  2. Synthesis of five-and six-membered cyclic guanidines by guanylation with isothiouronium iodides and amines under mild conditions  |  Aoyagi, N., & Endo, T. 2017. Synthetic Communications. 47(5): 442-448.
  3. Precise Synthesis of Side-Chain-Functionalized Linear Polysiloxanes by Organocatalytic Ring-Opening Polymerization of Monofunctional Cyclotrisiloxanes  |  Fuchise, K., Sato, K., & Igarashi, M. 2021. Macromolecules. 54(11): 5204-5217.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-(Methylthio)-1,4,5,6-tetrahydropyrimidine hydroiodide, 1 g

sc-259307
1 g
$306.00