2-Methoxy-antimycin A
QUICK LINKS
2-Methoxy-antimycin A3 is a compound that functions as an inhibitor of mitochondrial electron transport chain complex III. It exerts its mode of action by binding to the Qo site of the cytochrome b subunit, thereby blocking the transfer of electrons from ubiquinol to cytochrome c. This disruption leads to the inhibition of ATP synthesis and the generation of reactive oxygen species, ultimately causing mitochondrial dysfunction. 2-Methoxy-antimycin A3 can be used to study the role of complex III in cellular respiration and oxidative phosphorylation. Its ability to target the electron transport chain makes it useful for investigating mitochondrial function and the mechanisms underlying oxidative stress. Additionally, its mode of action provides insights into the regulation of cellular energy production and the potential implications for various physiological and pathological processes.
2-Methoxy-antimycin A References
- Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3. | Tzung, SP., et al. 2001. Nat Cell Biol. 3: 183-91. PMID: 11175751
- Real-time monitoring of lactate extrusion and glucose consumption of cultured cells using a lab-on-valve system. | Schulz, CM., et al. 2002. Analyst. 127: 1583-8. PMID: 12537364
- The BCL2-family of protein ligands as cancer drugs: the next generation of therapeutics. | Liu, W., et al. 2003. Curr Med Chem Anticancer Agents. 3: 217-23. PMID: 12769779
- Bcl-2-related proteins as drug targets. | O'Neill, JW. and Hockenbery, DM. 2003. Curr Med Chem. 10: 1553-62. PMID: 12871126
- Recent advances in the development of anticancer agents targeting cell death inhibitors in the Bcl-2 protein family. | Shangary, S. and Johnson, DE. 2003. Leukemia. 17: 1470-81. PMID: 12886234
- Promises and challenges of targeting Bcl-2 anti-apoptotic proteins for cancer therapy. | O'Neill, J., et al. 2004. Biochim Biophys Acta. 1705: 43-51. PMID: 15585172
- Targeted therapies for epithelial cancers: in vivo efficacy of the BCL-2/BCL-XL inhibitor 2-MeAA. | Schwartz, PS. and Hockenbery, DM. 2007. Cancer Biol Ther. 6: 465-6. PMID: 17471026
- 2-Methoxy antimycin reveals a unique mechanism for Bcl-x(L) inhibition. | Schwartz, PS., et al. 2007. Mol Cancer Ther. 6: 2073-80. PMID: 17620436
- Piercing the armor of hepatobiliary cancer: Bcl-2 homology domain 3 (BH3) mimetics and cell death. | Mott, JL. and Gores, GJ. 2007. Hepatology. 46: 906-11. PMID: 17654739
- Mitochondrial electron transport chain blockers enhance 2-deoxy-D-glucose induced oxidative stress and cell killing in human colon carcinoma cells. | Fath, MA., et al. 2009. Cancer Biol Ther. 8: 1228-36. PMID: 19411865
- Combining 2-deoxy-D-glucose with electron transport chain blockers: a double-edged sword. | Boutros, J. and Almasan, A. 2009. Cancer Biol Ther. 8: 1237-8. PMID: 19458493
- Antimycin A18 produced by an endophytic Streptomyces albidoflavus isolated from a mangrove plant. | Yan, LL., et al. 2010. J Antibiot (Tokyo). 63: 259-61. PMID: 20300130
- Multiple BH3 mimetics antagonize antiapoptotic MCL1 protein by inducing the endoplasmic reticulum stress response and up-regulating BH3-only protein NOXA. | Albershardt, TC., et al. 2011. J Biol Chem. 286: 24882-95. PMID: 21628457
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Methoxy-antimycin A, 1 mg | sc-396792 | 1 mg | $134.00 |