Molecular structure of 2-Guanidinoethylmercaptosuccinic Acid, CAS Number: 77482-44-1
2-Guanidinoethylmercaptosuccinic Acid (CAS 77482-44-1)
See product citations (3)
Alternate Names:
GEMSA
Application:
2-Guanidinoethylmercaptosuccinic Acid is a potent enkephalin convertase inhibitor
CAS Number:
77482-44-1
Purity:
≥99%
Molecular Weight:
235.2
Molecular Formula:
C7H13N3O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
2-Guanidinoethylmercaptosuccinic Acid, also knowns as GEMSA, is a potent inhibitor of enkephalin convertase (CPE Ki = 8.8 nM), known as a carboxypeptidase B-like processing enzyme. The compound may act to be a model candidate for use in affinity chromatography of the enzyme. Studies show that 2-Guanidinoethylmercaptosuccinic Acid can influence the endogenous opioid peptide system and have a dominant affect on the central nervous system. 2-Guanidinoethylmercaptosuccinic acid is an inhibitor of carboxypeptidase N, polypeptide 1 (CPN cat).
2-Guanidinoethylmercaptosuccinic Acid (CAS 77482-44-1) References
- Roles of thermal instability and proteolytic cleavage in regulation of activated thrombin-activable fibrinolysis inhibitor. | Boffa, MB., et al. 2000. J Biol Chem. 275: 12868-78. PMID: 10777585
- Purification, cloning, and characterization of a profibrinolytic plasminogen-binding protein, TIP49a. | Hawley, SB., et al. 2001. J Biol Chem. 276: 179-86. PMID: 11027681
- Stabilization versus inhibition of TAFIa by competitive inhibitors in vitro. | Walker, JB., et al. 2003. J Biol Chem. 278: 8913-21. PMID: 12643276
- The role of the S1 binding site of carboxypeptidase M in substrate specificity and turn-over. | Deiteren, K., et al. 2007. Biochim Biophys Acta. 1774: 267-77. PMID: 17208058
- Molecular characterization of the carboxypeptidase B1 of Anopheles stephensi and its evaluation as a target for transmission-blocking vaccines. | Raz, A., et al. 2013. Infect Immun. 81: 2206-16. PMID: 23569111
- In vivo modulation of rat hypothalamic opioid peptide content by intracerebroventricular injection of guanidinoethylmercaptosuccinic acid (GEMSA): possible physiological role of enkephalin convertase. | Bommer, M., et al. 1989. Brain Res. 492: 305-13. PMID: 2665903
- Analgesic and convulsant effects of guanidinoethylmercaptosuccinic acid (GEMSA)--a potent enkephalin convertase inhibitor. | Przewlocka, B., et al. 1986. Neuropeptides. 8: 359-65. PMID: 3102992
- Purification and characterization of TAFI, a thrombin-activable fibrinolysis inhibitor. | Bajzar, L., et al. 1995. J Biol Chem. 270: 14477-84. PMID: 7782309
- The profibrinolytic effect of activated protein C in clots formed from plasma is TAFI-dependent. | Bajzar, L., et al. 1996. Blood. 88: 2093-100. PMID: 8822928
- Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: involvement of insulin-degrading enzyme. | McDermott, JR. and Gibson, AM. 1997. Neurochem Res. 22: 49-56. PMID: 9021762
- Thrombin-mediated activation of factor XI results in a thrombin-activatable fibrinolysis inhibitor-dependent inhibition of fibrinolysis. | Von dem Borne, PA., et al. 1997. J Clin Invest. 99: 2323-7. PMID: 9153272
- Plasma and recombinant thrombin-activable fibrinolysis inhibitor (TAFI) and activated TAFI compared with respect to glycosylation, thrombin/thrombomodulin-dependent activation, thermal stability, and enzymatic properties. | Boffa, MB., et al. 1998. J Biol Chem. 273: 2127-35. PMID: 9442053
- A study of the mechanism of inhibition of fibrinolysis by activated thrombin-activable fibrinolysis inhibitor. | Wang, W., et al. 1998. J Biol Chem. 273: 27176-81. PMID: 9765237
Inhibitor of:
CPE, CPN cat, and Protease.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Guanidinoethylmercaptosuccinic Acid, 5 mg | sc-203769 | 5 mg | $300.00 |