2-Fluoroadenine (CAS 700-49-2)
QUICK LINKS
2-Fluoroadenine is a molecule of interest in biochemical research due to its structural similarity to adenine, one of the four nucleobase components of DNA and RNA. It is utilized in studies investigating the impact of halogenated nucleobases on DNA stability and function, which is essential for understanding the mutagenic effects of such substitutions. Research involving 2-Fluoroadenine also encompasses the exploration of its incorporation into nucleic acids and the subsequent consequences on transcription and translation processes. In the field of molecular biology, this compound is used to study enzyme-substrate interactions, particularly with enzymes involved in nucleotide metabolism. Additionally, 2-Fluoroadenine is relevant in the development of nucleoside analogs and their potential application in various non-clinical research scenarios.
2-Fluoroadenine (CAS 700-49-2) References
- Synthesis of carbocyclic and acyclic nucleosides possessing 2-fluoroadenine derivatives and their inhibitory activities against Plasmodium falciparum SAH hydrolase. | Kitade, Y., et al. 2003. Nucleic Acids Res Suppl. 5-6. PMID: 14510352
- Convenient synthesis of 2'-deoxy-2-fluoroadenosine from 2-fluoroadenine. | Ye, S., et al. 2003. Nucleosides Nucleotides Nucleic Acids. 22: 1899-905. PMID: 14609229
- Preparation of a fludarabine intermediate via selective alkylation of 2-fluoroadenine. | Schulmeier, BE., et al. 2006. Nucleosides Nucleotides Nucleic Acids. 25: 735-45. PMID: 16898412
- Structure of a mutant human purine nucleoside phosphorylase with the prodrug, 2-fluoro-2'-deoxyadenosine and the cytotoxic drug, 2-fluoroadenine. | Afshar, S., et al. 2009. Protein Sci. 18: 1107-14. PMID: 19388075
- An efficient synthesis of the 4'-epimer of 2-fluoronoraristeromycin. | Bazile, Q., et al. 2012. Tetrahedron Lett. 53: 1435-1437. PMID: 22690021
- The First Bagshawe lecture. Towards generating cytotoxic agents at cancer sites. | Bagshawe, KD. 1989. Br J Cancer. 60: 275-81. PMID: 2675955
- Sensitizing DNA Towards Low-Energy Electrons with 2-Fluoroadenine. | Rackwitz, J., et al. 2016. Angew Chem Int Ed Engl. 55: 10248-52. PMID: 27481662
- Receptor-mediated gene delivery and expression in vivo. | Wu, GY. and Wu, CH. 1988. J Biol Chem. 263: 14621-4. PMID: 3049582
- Establishment of a Genome Editing Tool Using CRISPR-Cas9 in Chlorella vulgaris UTEX395. | Kim, J., et al. 2021. Int J Mol Sci. 22: PMID: 33418923
- Apt (Adenine Phosphoribosyltransferase) Mutation in Laboratory-Selected Vancomycin-Intermediate Staphylococcus aureus. | Lamichhane-Khadka, R., et al. 2021. Antibiotics (Basel). 10: PMID: 34069103
- Targeted CRISPR-Cas9-based gene knockouts in the model brown alga Ectocarpus. | Badis, Y., et al. 2021. New Phytol. 231: 2077-2091. PMID: 34076889
- Characterization of 2-Fluoro-2'-deoxyadenosine in Duplex, G-Quadruplex and i-Motif. | Hirashima, S., et al. 2022. Chembiochem. 23: e202200222. PMID: 35438834
- Construction and characterization of an Escherichia coli strain with a uncI mutation. | Gay, NJ. 1984. J Bacteriol. 158: 820-5. PMID: 6327640
- Differential mechanism of cytostatic effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine, 9-(1,3-dihydroxy-2-propoxymethyl)guanine, and other antiherpetic drugs on tumor cells transfected by the thymidine kinase gene of herpes simplex virus type 1 or type 2. | Balzarini, J., et al. 1993. J Biol Chem. 268: 6332-7. PMID: 8384209
- Metabolism and metabolic actions of 6-methylpurine and 2-fluoroadenine in human cells. | Parker, WB., et al. 1998. Biochem Pharmacol. 55: 1673-81. PMID: 9634004
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Fluoroadenine, 250 mg | sc-216197 | 250 mg | $100.00 | |||
2-Fluoroadenine, 5 g | sc-216197A | 5 g | $270.00 | |||
2-Fluoroadenine, 25 g | sc-216197B | 25 g | $1300.00 |