Date published: 2026-4-26

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2-Di-tert-butylphosphino-2′-(N,N-dimethylamino)biphenyl (CAS 224311-49-3)

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Alternate Names:
t-BuDavePhos
CAS Number:
224311-49-3
Molecular Weight:
341.47
Molecular Formula:
C22H32NP
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-(Di-tert-butylphosphino)-2′-(N,N-dimethylamino)biphenyl, known as DTB-DMAB, serves as a versatile phosphine ligand pivotal in metal-catalyzed reactions across diverse applications. Its extensive examination stems from its distinctive capacity to interact with a range of metals, including palladium, rhodium, cobalt, and nickel. Such distinctive traits render it an optimal ligand for manifold laboratory uses.Within the realm of scientific exploration, 2-(Di-tert-butylphosphino)-2′-(N,N-dimethylamino)biphenyl enjoys widespread utilization. It finds its role in a spectrum of reactions like hydroformylation, hydrogenation, and carbonylation. Notably, its involvement extends to synthesizing an assortment of organic compounds, encompassing polymers, and dyes,.The operative mechanism of 2-(Di-tert-butylphosphino)-2′-(N,N-dimethylamino)biphenyl rests on its proficiency in attaching to diverse metals, such as palladium, rhodium, cobalt, and nickel.


2-Di-tert-butylphosphino-2′-(N,N-dimethylamino)biphenyl (CAS 224311-49-3) References

  1. A tandem Heck-carbocyclization/Suzuki-coupling approach to the stereoselective syntheses of asymmetric 3,3-(diarylmethylene)indolinones.  |  Cheung, WS., et al. 2005. J Org Chem. 70: 3741-4. PMID: 15845020
  2. A simple and efficient copper-catalyzed procedure for the hydrosilylation of hindered and functionalized ketones.  |  Díez-González, S., et al. 2005. J Org Chem. 70: 4784-96. PMID: 15932319
  3. Synthesis of Diversely Functionalized Oxindoles Enabled by Migratory Insertion of Isocyanide to a Transient σ-Alkylpalladium(II) Complex.  |  Kong, W., et al. 2016. Angew Chem Int Ed Engl. 55: 9714-8. PMID: 27356093
  4. Ylide-Functionalized Phosphine (YPhos)-Palladium Catalysts: Selective Monoarylation of Alkyl Ketones with Aryl Chlorides.  |  Hu, XQ., et al. 2019. Org Lett. 21: 7558-7562. PMID: 31469570
  5. Multiple Catalytic C-H Bond Functionalization for Natural Product Synthesis.  |  Baudoin, O. 2020. Angew Chem Int Ed Engl. 59: 17798-17809. PMID: 32220111

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Di-tert-butylphosphino-2′-(N,N-dimethylamino)biphenyl, 1 g

sc-225334
1 g
$359.00