Date published: 2025-9-26

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2-Aminoanthracene (CAS 613-13-8)

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Alternate Names:
2-Anthramine
CAS Number:
613-13-8
Molecular Weight:
193.24
Molecular Formula:
C14H11N
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Aminoanthracene functions as a mutagen and carcinogen in experiment. It exerts its mechanism of action by intercalating into DNA, causing structural distortions and interfering with DNA replication and transcription processes. 2-Aminoanthracene induce mutations by causing base pair substitutions and frameshift mutations, leading to genetic instability and potential tumorigenesis. 2-Aminoanthracene has been used to study the molecular mechanisms of mutagenesis and carcinogenesis, providing insights into the DNA damage and repair pathways. Its ability to induce genetic mutations makes it useful in investigating the effects of DNA damage on cellular processes and the development of cancer. In experiment, 2-Aminoanthracene′s mechanism of action involves its interaction with DNA at the molecular level, contributing to the understanding of mutagenic processes and genetic alterations.


2-Aminoanthracene (CAS 613-13-8) References

  1. 2-aminoanthracene as an analytical tool with the acetylation reaction catalyzed by arylamine N-acetyltransferase.  |  Servillo, L., et al. 1999. Anal Biochem. 273: 105-10. PMID: 10452805
  2. Dietary exposure to 2-aminoanthracene induces morphological and immunocytochemical changes in pancreatic tissues of Fisher-344 rats.  |  Boudreau, MD., et al. 2006. Toxicol Sci. 93: 50-61. PMID: 16760417
  3. 2-Aminoanthracene, 5-fluorouracil, colchicine, benzo[a]pyrene, cadmium chloride and cytosine arabinoside tested in the in vitro mammalian cell micronucleus test (MNvit) in Chinese hamster ovary (CHO) cells at Covance Laboratories, Harrogate UK in support of OECD draft Test Guideline 487.  |  Whitwell, J., et al. 2010. Mutat Res. 702: 237-47. PMID: 20478394
  4. 2-Aminoanthracene, diethylstilboestrol and vinblastine tested in the in vitro mammalian cell micronucleus test at British American Tobacco UK in support of the OECD draft Test Guideline 487.  |  Massey, ED. and Hinchliffe, S. 2010. Mutat Res. 702: 208-11. PMID: 21212042
  5. Effect of troxerutin on 2-aminoanthracene and DNA interaction and its anti-mutagenic property.  |  Subastri, A., et al. 2017. Biomed Pharmacother. 88: 325-334. PMID: 28119234
  6. Inflammatory effect of 2-aminoanthracene (2AA) on adipose tissue gene expression in pregnant Sprague Dawley rats.  |  Whitby, SL., et al. 2016. Interdiscip Toxicol. 9: 17-24. PMID: 28652843
  7. Investigating the toxic effects of 2-aminoanthracene ingestion in pregnant Sprague Dawley dams.  |  Wilson, HK., et al. 2018. J Environ Sci Health B. 53: 283-289. PMID: 29293381
  8. Ag@SiO2 nanoparticles performing as a nanoprobe for selective analysis of 2-aminoanthracene in wastewater samples via metal-enhanced fluorescence.  |  Jin, T., et al. 2019. Talanta. 200: 242-248. PMID: 31036180
  9. The hepatic effects in dams that ingested 2-aminoanthracene during gestation and lactation.  |  Ulieme, RE., et al. 2019. Toxicol Ind Health. 35: 568-576. PMID: 31558114
  10. Evaluation of renal markers of T1D in Sprague-Dawley exposed to 2-aminoanthracene.  |  Pierre, TH., et al. 2020. Environ Toxicol. 35: 203-212. PMID: 31714650
  11. Dietary ingestion of 2-aminoanthracene (2AA) and the risk for type-1 diabetes (T1D).  |  Seise, I., et al. 2020. J Environ Sci Health A Tox Hazard Subst Environ Eng. 55: 1638-1645. PMID: 33377427
  12. 4-Ipomeanol and 2-aminoanthracene cytotoxicity in C3H/10T1/2 cells expressing rabbit cytochrome P450 4B1.  |  Smith, PB., et al. 1995. Biochem Pharmacol. 50: 1567-75. PMID: 7503758
  13. Inhibition of metabolic activation of the promutagens, benzo[a]pyrene, 2-aminofluorene and 2-aminoanthracene by furanochromones in Salmonella typhimurium.  |  Schimmer, O. and Rauch, P. 1998. Mutagenesis. 13: 385-9. PMID: 9717176

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Aminoanthracene, 1 g

sc-237908
1 g
$30.00