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2-Amino-5-methylphenol (CAS 2835-98-5)

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Alternate Names:
6-Amino-m-cresol; 2-Hydroxy-4-methylaniline; 4-Amino-3-hydroxytoluen
Application:
2-Amino-5-methylphenol is a novel non-metallocene catalyst with phenoxy-imine ligands and used in the synthesis of tridentate Schiff base ligand
CAS Number:
2835-98-5
Purity:
98%
Molecular Weight:
123.15
Molecular Formula:
C7H9NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Amino-5-methylphenol can react with bovine hemoglobin to form 2-amino-4,4alpha-dihydro-4alpha-7-dimethyl-3H-phenoxazine-3-one. This can inhibit Poliovirus proliferation in Vero cells, and is converted to dihydrophenoxazinone by purified human hemoglobin. 2-Amino-5-methylphenol, a derivative of phenol, has been investigated in vitro to assess its impact on diverse biological processes. Through these studies, researchers have utilized 2-amino-5-methylphenol to explore its effects on cellular metabolism and the expression of genes, providing valuable insights into the mechanisms underlying drug interactions and compound-mediated regulation of enzyme activity. By employing 2-amino-5-methylphenol as a tool, scientists have expanded their understanding of the intricate interplay between compounds and biological systems, facilitating advancements in the fields of pharmacology and enzymology.


2-Amino-5-methylphenol (CAS 2835-98-5) References

  1. Antitumor effects of a novel phenoxazine derivative on human leukemia cell lines in vitro and in vivo.  |  Shimamoto, T., et al. 2001. Clin Cancer Res. 7: 704-8. PMID: 11297267
  2. An improved method for the rapid preparation of 2-amino-4,4a-dihydro-4a,7-dimethyl-3H-phenoxazine-3-one, a novel antitumor agent.  |  Tomoda, A., et al. 2001. Bioorg Med Chem Lett. 11: 1057-8. PMID: 11327588
  3. Prevention of growth of human lung carcinoma cells and induction of apoptosis by a novel phenoxazinone, 2-amino-4,4alpha-dihydro-4alpha,7-dimethyl-3H-phenoxazine-3-one.  |  Abe, A., et al. 2001. Anticancer Drugs. 12: 377-82. PMID: 11335795
  4. Antitumor activity of a phenoxazine compound, 2-amino-4,4alpha-dihydro-4alpha,7-dimethyl-3H-phenoxazine-3-one against human B cell and T cell lymphoblastoid cell lines: induction of mixed types of cell death, apoptosis, and necrosis.  |  Koshibu-Koizumi, J., et al. 2002. J Cancer Res Clin Oncol. 128: 363-8. PMID: 12136250
  5. Phenoxazinone synthesis by human hemoglobin.  |  Tomoda, A., et al. 1992. Biochim Biophys Acta. 1117: 306-14. PMID: 1329970
  6. Antiviral activity of 2-amino-4,4alpha-dihydro-4alpha-7-dimethyl-3H-phenoxazine-3-one on poliovirus.  |  Iwata, A., et al. 2003. Tohoku J Exp Med. 200: 161-5. PMID: 14521260
  7. Vibrational spectroscopy investigation using ab initio and density functional theory analysis on the structure of 2-amino-5-methylphenol.  |  Sundaraganesan, N., et al. 2007. Spectrochim Acta A Mol Biomol Spectrosc. 67: 550-8. PMID: 16996297
  8. Oxidative condensation of 2-amino-4-methylphenol to dihydrophenoxazinone compound by human hemoglobin.  |  Tomoda, A., et al. 1991. J Biochem. 110: 1004-7. PMID: 1794970
  9. A novel kinetic determination of dissolved chromium species in natural and industrial waste water.  |  Mohamed, AA., et al. 2006. Talanta. 70: 460-7. PMID: 18970793
  10. Solvent-free Mechanosynthesis of Two Thermochromic Schiff Bases.  |  Kaitner, B. and Zbačnik, M. 2012. Acta Chim Slov. 59: 670-9. PMID: 24061325
  11. Expression and characterization of an N-oxygenase from Rhodococcus jostii RHAI.  |  Indest, KJ., et al. 2015. J Gen Appl Microbiol. 61: 217-23. PMID: 26782651
  12. Antitumor activity of 2-amino-4,4 alpha-dihydro-4 alpha, 7-dimethyl-3H-phenoxazine-3-one, a novel phenoxazine derivative produced by the reaction of 2-amino-5-methylphenol with bovine hemolysate.  |  Ishida, R., et al. 1996. Anticancer Drugs. 7: 591-5. PMID: 8862728
  13. Synthesis and theoretic calculations of benzoxazoles and docking studies of their interactions with triosephosphate isomerase  |  César A. Flores Sandoval, Roberto I. Cuevas Hernández, José Correa Basurto, Hiram I. Beltrán Conde, Itzia I. Padilla Martínez, José N. Farfán García, Benjamín Nogueda Torres & José G. Trujillo Ferrara. 2013. Medicinal Chemistry Research. 22: 2768–2777.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Amino-5-methylphenol, 10 g

sc-225147
10 g
$38.00