2-Acetamido-2-deoxy-3,4,6-tri-O-acetyl-β-D-glucopyranosylamine (CAS 4515-24-6)

2-Acetamido-2-deoxy-3,4,6-tri-O-acetyl-β-D-glucopyranosylamine is a chemically modified derivative of N-acetylglucosamine, commonly used in glycobiology research. This compound serves as a valuable substrate for enzymatic glycosylation reactions and as a precursor for the synthesis of structurally diverse glycoconjugates and oligosaccharides. Its acetyl groups provide protection for the hydroxyl groups, enabling selective deprotection and functionalization at specific positions on the sugar scaffold. Researchers have utilized this compound in the synthesis of complex glycan structures for investigating carbohydrate-protein interactions, glycan biosynthesis pathways, and glycan-mediated biological processes. Additionally, it has been employed in the development of glycan microarrays, glycopeptides, and glycolipids for studying host-pathogen interactions, immune responses, and cell signaling events. Furthermore, 2-Acetamido-2-deoxy-3,4,6-tri-O-acetyl-β-D-glucopyranosylamine has been used as a precursor in the synthesis of glycosylated natural products, glycosaminoglycans, and glycoconjugate vaccines for applications in chemical biology, drug discovery, and vaccine development. Its versatility and synthetic accessibility make it an essential tool for unraveling the roles of glycans in various biological processes and for developing novel glycan-based diagnostics.