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2,2,2-Trifluoroethanol (CAS 75-89-8)

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Alternate Names:
TFE
Application:
2,2,2-Trifluoroethanol is an acidic alcohol that forms stable complexes with heterocycles
CAS Number:
75-89-8
Purity:
≥99%
Molecular Weight:
100.04
Molecular Formula:
C2H3F3O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2,2,2-Trifluoroethanol (TFE) exhibits itself as a colorless liquid with a recognizable odor. This volatile, flammable, and mildly toxic compound demonstrates solubility in water as well as numerous organic solvents. 2,2,2-Trifluoroethanol finds extensive applications within the chemical industries, alongside its utilization in scientific research. Whether serving as a solvent, a reagent, or an ingredient within various mixtures, it showcases its versatility. Moreover, 2,2,2-Trifluoroethanol acts as a catalyst in organic synthesis, a preservative, and a stabilizer for specific reactions. Within the realm of scientific research, 2,2,2-Trifluoroethanol assumes a prominent role. It functions as a solvent during the synthesis of diverse compounds, including peptides, polymers, and various organic substances. Additionally, it serves as useful for exploring the intricate structure and functionality of proteins and other biological molecules. 2,2,2-Trifluoroethanol operates as a solvent for an array of organic compounds. Its low dielectric constant enables the dissolution of numerous organic substances that are insoluble in water. Furthermore, it acts as an effective solvent for polar compounds, such as proteins and nucleic acids. Notably, it can exert catalytic effects on specific reactions, such as the hydrolysis of esters.


2,2,2-Trifluoroethanol (CAS 75-89-8) References

  1. 2,2,2-Trifluoroethanol-Induced structural change of peanut agglutinin at different pH: A comparative account.  |  Dev, S., et al. 2006. IUBMB Life. 58: 473-9. PMID: 16916785
  2. 2,2,2-Trifluoroethanol changes the transition kinetics and subunit interactions in the small bacterial mechanosensitive channel MscS.  |  Akitake, B., et al. 2007. Biophys J. 92: 2771-84. PMID: 17277184
  3. Interactions of 2,2,2-trifluoroethanol with melittin.  |  Neuman, RC. and Gerig, JT. 2009. Magn Reson Chem. 47: 925-31. PMID: 19634131
  4. Conformation of 2,2,2-trifluoroethanol and the solvation structure of its 2-fluoropyridine clusters.  |  Yamada, Y., et al. 2012. J Phys Chem A. 116: 2845-54. PMID: 22364619
  5. 2,2,2-Trifluoroethanol disrupts the triple helical structure and self-association of type I collagen.  |  Shanmugam, G., et al. 2013. Int J Biol Macromol. 54: 155-9. PMID: 23246674
  6. 1,2-diazole and 2,2,2-trifluoroethanol and their regulatory effects on ethanol and lactic acid formation in the living culture of Rhizopus oryzae.  |  Thitiprasert, S., et al. 2014. Appl Biochem Biotechnol. 172: 1673-86. PMID: 24242164
  7. Anesthetic 2,2,2-trifluoroethanol induces amyloidogenesis and cytotoxicity in human serum albumin.  |  Naeem, A., et al. 2015. Int J Biol Macromol. 79: 726-35. PMID: 26038104
  8. Multiple aspects of the toxicity of fluroxene and its metabolite 2,2,2-trifluoroethanol.  |  Kaminsky, LS. and Fraser, JM. 1988. Crit Rev Toxicol. 19: 87-112. PMID: 2906849
  9. Assessment of the Role of 2,2,2-Trifluoroethanol Solvent Dynamics in Inducing Conformational Transitions in Melittin: An Approach with Solvent 19F Low-Field NMR Relaxation and Overhauser Dynamic Nuclear Polarization Studies.  |  Chaubey, B., et al. 2020. J Phys Chem B. 124: 5993-6003. PMID: 32573229
  10. 2,2,2-Trifluoroethanol-induced enteropathy in rats: chemically or bacterially mediated effects.  |  Kim, JC., et al. 1987. Toxicol Pathol. 15: 388-400. PMID: 3324284
  11. 2,2,2-Trifluoroethanol toxicity in aged rats.  |  Kim, JC. and Kaminsky, LS. 1988. Toxicol Pathol. 16: 35-45. PMID: 3375746
  12. 2,2,2-Trifluoroethanol-mediated hydroarylation of fluorinated alkynes with indoles: Application to diindolylmethanes.  |  Flury, P., et al. 2022. Arch Pharm (Weinheim). 355: e2100488. PMID: 35467043
  13. Metabolism of 2,2,2-trifluoroethanol and its relationship to toxicity.  |  Fraser, JM. and Kaminsky, LS. 1987. Toxicol Appl Pharmacol. 89: 202-10. PMID: 3603557

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2,2,2-Trifluoroethanol, 25 g

sc-238237
25 g
$31.00

2,2,2-Trifluoroethanol, 100 g

sc-238237A
100 g
$51.00