Date published: 2025-12-1

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2,2,2-Trifluoro-N-phenylacetimidoyl Chloride (CAS 61881-19-4)

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CAS Number:
61881-19-4
Molecular Weight:
207.58
Molecular Formula:
C8H5ClF3N
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2,2,2-Trifluoro-N-phenylacetimidoyl chloride, with its distinctive trifluoroacetimidoyl group attached to a phenyl ring via a nitrogen atom and further functionalized with a reactive chloride, is a versatile reagent in organic synthesis, particularly in the realm of material science and chemical research. The presence of the trifluoro group significantly alters the electronic properties of the molecule, enhancing its reactivity and making it an excellent candidate for nucleophilic substitution reactions. This compound is particularly useful in the synthesis of complex organic molecules, including fluorinated compounds, where the trifluoro group can impart desirable physical and chemical properties such as increased stability, volatility, or bioactivity, without direct involvement in bioactive research. Its utility lies not only in its ability to act as a building block for more complex structures but also in its role as a stepping stone in the exploration of reaction mechanisms and the development of new synthetic methodologies. Through its application, researchers can elucidate the subtleties of fluorine chemistry, offering insights into the interaction between fluorinated compounds and organic substrates, thereby expanding the toolkit available for chemical synthesis and the design of new materials with tailored properties.


2,2,2-Trifluoro-N-phenylacetimidoyl Chloride (CAS 61881-19-4) References

  1. A general and straightforward method for the synthesis of 2-trifluoromethylbenzothiazoles.  |  Zhu, J., et al. 2010. Org Lett. 12: 2434-6. PMID: 20402511
  2. Regenerative glycosylation under nucleophilic catalysis.  |  Nigudkar, SS., et al. 2014. J Am Chem Soc. 136: 921-3. PMID: 24393099
  3. 3-(Dimethylamino)-1-propylamine: a cheap and versatile reagent for removal of byproducts in carbohydrate chemistry.  |  Andersen, SM., et al. 2015. Org Lett. 17: 944-7. PMID: 25647186
  4. Synthesis of Staphylococcus aureus Type 5 trisaccharide repeating unit: solving the problem of lactamization.  |  Gagarinov, IA., et al. 2015. Org Lett. 17: 928-31. PMID: 25658811
  5. Total synthesis of astrosterioside A, an anti-inflammatory asterosaponin.  |  Dai, Y. and Yu, B. 2015. Chem Commun (Camb). 51: 13826-9. PMID: 26234958
  6. Synthesis of a Glycosylphosphatidylinositol Anchor Derived from Leishmania donovani That Can Be Functionalized by Cu-Catalyzed Azide-Alkyne Cycloadditions.  |  Ding, N., et al. 2017. Org Lett. 19: 3827-3830. PMID: 28696125
  7. Protecting-Group-Controlled Enzymatic Glycosylation of Oligo-N-Acetyllactosamine Derivatives.  |  Gagarinov, IA., et al. 2019. Angew Chem Int Ed Engl. 58: 10547-10552. PMID: 31108002
  8. Comparison of disaccharide donors for heparan sulfate synthesis: uronic acids vs. their pyranose equivalents.  |  Sheppard, DJ., et al. 2020. Org Biomol Chem. 18: 4728-4733. PMID: 32531013
  9. Total Synthesis of a Partial Structure from Arabinogalactan and Its Application for Allergy Prevention.  |  Krumb, M., et al. 2021. Chemistry. 27: 928-933. PMID: 32579239
  10. Sequential Linkage of Carbohydrate Antigens to Mimic Capsular Polysaccharides: Toward Semisynthetic Glycoconjugate Vaccine Candidates against Streptococcus pneumoniae Serotype 14.  |  Seco, BMS., et al. 2020. ACS Chem Biol. 15: 2395-2405. PMID: 32835479
  11. Friedel-Crafts synthesis of bis(trifluoromethylated)-4-aryl-3,4-dihydroquinazolines, bis(trifluoromethylated)-3,4-dihydroquinazoline-4-ols and trifluoromethyl arylketoimines using N-aryltrifluoroacetimidoyl chlorides and benzene derivatives.  |  Kazemi, E., et al. 2022. Mol Divers. 26: 815-825. PMID: 33534024
  12. Synthesis, crystal structure, and catalytic properties of a copper(I) complex with 3H-(1,2,3)triazolo(4,5-b)pyridin-3-ol  |  Zhi-Rong Luo, et al. 2017. Journal of Coordination Chemistry. 70 (23): 3920-3930.
  13. Investigation of protecting group for sialic acid carboxy moiety toward sialylglycopeptide synthesis by the TFA-labile protection strategy  |  S Ito, Y Asahina, H Hojo. 2021. Tetrahedron. 97: 132423.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2,2,2-Trifluoro-N-phenylacetimidoyl Chloride, 5 g

sc-476903
5 g
$315.00