2-(1-Hydroxypentyl)-6-methyl-3-(2-phenylethyl)-1H-indole-5-carboxylic Acid (CAS 873841-43-1)

AM-251, scientifically known as 2-(1-Hydroxypentyl)-6-methyl-3-(2-phenylethyl)-1H-Indole-5-carboxylic acid, is a synthetic antagonist of the cannabinoid receptor. It has garnered significant attention in research for its potential therapeutic applications and its role as useful in understanding the endocannabinoid system. Extensive scientific research has utilized 2-(1-Hydroxypentyl)-6-methyl-3-(2-phenylethyl)-1H-Indole-5-carboxylic acid to investigate the intricate workings of the endocannabinoid system. Acting as a potent antagonist, it specifically targets the CB1 receptor, the primary receptor associated with the endocannabinoid system in the brain. By obstructing the CB1 receptor, researchers gain insights into the effects of the endocannabinoid system on various physiological processes. The mechanism of action of 2-(1-Hydroxypentyl)-6-methyl-3-(2-phenylethyl)-1H-Indole-5-carboxylic acid involves binding to the CB1 receptor and impeding the interaction of endocannabinoids such as anandamide and 2-arachidonoylglycerol. Consequently, the activity of the endocannabinoid system decreases. As the endocannabinoid system influences numerous physiological processes encompassing pain sensation, appetite, and mood regulation, inhibiting its activity has implications in these areas. Notably, animal studies have exhibited the potential of 2-(1-Hydroxypentyl)-6-methyl-3-(2-phenylethyl)-1H-Indole-5-carboxylic acid to decrease food intake and body weight, suggesting its viability as an anti-obesity treatment. Additionally, its ability to alleviate pain sensation and reduce inflammation implies its possible role in addressing chronic pain conditions.