17-β Estradiol Antibody (5E500): sc-69961

17-β Estradiol Antibody (5E500) is a mouse monoclonal IgG1 antibody that detects 17-beta Estradiol in mouse, rat, and human samples through the application of enzyme-linked immunosorbent assay (ELISA). Anti-17-beta Estradiol antibody (5E500) is offered as a non-conjugated format, providing researchers with a reliable tool for studying this critical hormone. 17-β Estradiol is a potent mammalian estrogenic hormone primarily produced in the ovaries by granulosa cells, as well as in the placenta, testis, and potentially the adrenal cortex. The synthesis of 17-β Estradiol involves enzymatic conversion from precursors such as acetate, cholesterol, progesterone, and testosterone. 17-β Estradiol extends beyond regulating reproductive anatomy and secondary sex characteristics; this hormone is also vital for bone growth, brain development, and the modulation of intracellular calcium levels and second messenger molecules. 17-β Estradiol has shown protective effects on various cell types following trauma-hemorrhage, enhancing circulation through aortic relaxation and exhibiting anti-apoptotic properties in endothelial cells. 17-β Estradiol plays a significant role in mitigating hydrogen peroxide-induced apoptosis via estrogen receptor-dependent activation of caspases-9 and -3 in rat endothelial cells, highlighting its importance in cellular survival and function.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

17-β Estradiol Antibody (5E500) References:

1. The atheroprotective effect of 17 beta-estradiol is not altered in P-selectin- or ICAM-1-deficient hypercholesterolemic mice.  |  Gourdy, P., et al. 2003. Atherosclerosis. 166: 41-8. PMID: 12482549
2. Dose-dependent inhibition of mitochondrial ATP synthase by 17 beta-estradiol.  |  Massart, F., et al. 2002. Gynecol Endocrinol. 16: 373-7. PMID: 12587531
3. Biphasic effects of 17-beta-estradiol on expression of occludin and transendothelial resistance and paracellular permeability in human vascular endothelial cells.  |  Ye, L., et al. 2003. J Cell Physiol. 196: 362-9. PMID: 12811830
4. 17 beta-estradiol/levonorgestrel transdermal system.  |  Dando, TM. and Perry, CM. 2004. Treat Endocrinol. 3: 319-24. PMID: 15330679
5. 17 Beta-estradiol-induced antidepressant-like effect in the forced swim test is absent in estrogen receptor-beta knockout (BERKO) mice.  |  Rocha, BA., et al. 2005. Psychopharmacology (Berl). 179: 637-43. PMID: 15645223
6. Short-term administration of 17-beta estradiol to outbred male CD-1 mice induces changes in the immune system, but not in reproductive organs.  |  Karpuzoglu-Sahin, E., et al. 2005. Immunol Invest. 34: 1-26. PMID: 15773569
7. Intranasal continuous combined 17 beta-estradiol/norethisterone therapy improves the lipid profile in healthy postmenopausal women.  |  Hemelaar, M., et al. 2006. Fertil Steril. 85: 979-88. PMID: 16580384
8. 17 beta-estradiol administration following trauma-hemorrhage prevents the increase in Kupffer cell cytokine production and MAPK activation predominately via estrogen receptor-alpha.  |  Suzuki, T., et al. 2006. Surgery. 140: 141-8. PMID: 16904963
9. 17-beta-Estradiol upregulates COX-2 in the rat oviduct.  |  Pérez Martínez, S., et al. 2006. Prostaglandins Other Lipid Mediat. 80: 155-64. PMID: 16939880

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-17-β Estradiol Antibody (5E500) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-17-β Estradiol Antibody (5E500) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

17-β Estradiol Antibody (5E500) Specifications

Alternate Product Name: 17-β Estradiol

Product Clone Name: 5E500

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: 17-β Estradiol

Epitope Species:

Product Reactivity/Detection: 17-β Estradiol-BSA conjugate and free estradiol

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for 17-β Estradiol Antibody (5E500): N/A