16(17)-EpDPE
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An unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators.1,2 Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids produces epoxides such as 14(15)-EpETrE which are prime candidates for the actual active mediator.3 However, the CYP450 metabolites of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been little studied relative to arachidonate epoxygenase metabolites. Is the DHA homolog of 14(15)-EpETrE, derived via epoxidation of the 16,17-double bond of docosahexaenoic acid (DHA). The EDHF activity of 16(17)-EpDPE has not yet been determined and the epoxygenase metabolites of DHA have also been detected in a murine inflammation model.4
16(17)-EpDPE References
- Anti-inflammatory ω-3 endocannabinoid epoxides. | McDougle, DR., et al. 2017. Proc Natl Acad Sci U S A. 114: E6034-E6043. PMID: 28687674
- Effects of inflammation and soluble epoxide hydrolase inhibition on oxylipin composition of very low-density lipoproteins in isolated perfused rat livers. | Walker, RE., et al. 2021. Physiol Rep. 9: e14480. PMID: 33625776
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
16(17)-EpDPE, 25 µg | sc-220642 | 25 µg | $43.00 | |||
16(17)-EpDPE, 50 µg | sc-220642A | 50 µg | $81.00 |