Molecular structure of 13(S)-HPODE, CAS Number: 33964-75-9
13(S)-HPODE (CAS 33964-75-9)
See product citations (4)
Application:
13(S)-HPODE is a hydroperoxide formed from the oxidation of linoleic acid shown to inhibit platelet aggregation
CAS Number:
33964-75-9
Purity:
98%
Molecular Weight:
312.5
Molecular Formula:
C18H32O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
13(S)-HPODE is a hydroperoxide formed from the oxidation of linoleic acid shown to be a potent suppressor of platelets. Other effects include inhibiting prostacyclin synthase and activating PPARalpha in rat Fao, but not in human HepG2 hepatoma cell lines. In laboratory tests, 13(S)-HPODE was found to reduce systemic blood pressure, decrease heart rate, alter the EKG T wave, produce endothelial injuries, and constrict coronary arteries. The cytotoxicity of this product has been observed to be attenuated by Neu5Ac acid.
13(S)-HPODE (CAS 33964-75-9) References
- Analysis of FeII-mediated decomposition of a linoleic acid-derived lipid hydroperoxide by liquid chromatography/mass spectrometry. | Lee, SH., et al. 2005. J Mass Spectrom. 40: 661-8. PMID: 15739161
- Differential action of 13-HPODE on PPARalpha downstream genes in rat Fao and human HepG2 hepatoma cell lines. | König, B. and Eder, K. 2006. J Nutr Biochem. 17: 410-8. PMID: 16216487
- Metabolism of oxidized linoleic acid by glutathione transferases: peroxidase activity toward 13-hydroperoxyoctadecadienoic acid. | Seeley, SK., et al. 2006. Biochim Biophys Acta. 1760: 1064-70. PMID: 16624487
- Sialic acid attenuates the cytotoxicity of the lipid hydroperoxides HpODE and HpETE. | Iijima, R., et al. 2009. Carbohydr Res. 344: 933-5. PMID: 19329108
- L-4F differentially alters plasma levels of oxidized fatty acids resulting in more anti-inflammatory HDL in mice. | Imaizumi, S., et al. 2010. Drug Metab Lett. 4: 139-48. PMID: 20642447
- An insight into the regiospecificity of linoleic acid peroxidation catalyzed by mammalian 15-lipoxygenases. | Suardíaz, R., et al. 2013. J Phys Chem B. 117: 3747-54. PMID: 23496802
- The anti-atherosclerotic effect of tanshinol borneol ester using fecal metabolomics based on liquid chromatography-mass spectrometry. | Jia, P., et al. 2016. Analyst. 141: 1112-20. PMID: 26689835
- Hydroxy- and hydroperoxy derivatives of linoleic and arachidonic acid suppress the activation of rabbit blood platelets. | Bult, H., et al. 1987. Adv Prostaglandin Thromboxane Leukot Res. 17A: 224-8. PMID: 2959053
- IL-13 and the hydroperoxy fatty acid 13(S)HpODE play crucial role in inducing an apoptotic pathway in cancer cells involving MAO-A/ROS/p53/p21 signaling axis. | Biswas, P., et al. 2023. Free Radic Biol Med. 195: 309-328. PMID: 36592660
- The Synergism of Human Lactobacillaceae and Inulin Decrease Hyperglycemia via Regulating the Composition of Gut Microbiota and Metabolic Profiles in db/db Mice. | Li, P., et al. 2023. J Microbiol Biotechnol. 33: 1657-1670. PMID: 37734909
- Experimental myocardial infarction: effects of a lipid peroxide, 13-hydroperoxy linoleic acid on coronary circulation in rats. | Mizukami, M., et al. 1984. Arzneimittelforschung. 34: 569-71. PMID: 6540574
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
13(S)-HPODE, 50 µg | sc-200964 | 50 µg | $86.00 | |||
13(S)-HPODE, 1 mg | sc-200964A | 1 mg | $835.00 |