13(R)-HODE (CAS 10219-69-9)

13(R)-HODE, with the CAS number 10219-69-9, represents the R-enantiomer of 13-hydroxyoctadecadienoic acid, a metabolite produced predominantly through the enzymatic oxidation of linoleic acid by 15-lipoxygenases. This specific enantiomer is of great interest in biochemical research due to its unique properties and roles in cellular mechanisms. As a signaling molecule, 13(R)-HODE is involved in the regulation of a host of cellular processes, including the modulation of inflammatory responses and the stabilization of cellular structures through its interaction with lipid membranes. It plays a critical role in understanding the mechanisms of lipid signaling that influence cell behavior, particularly in the context of oxidative stress and inflammation. In experimental research, 13(R)-HODE is utilized to explore its effects on various signaling pathways, including those related to apoptosis, cell differentiation, and immune cell regulation. Its ability to bind and activate specific receptors, such as peroxisome proliferator-activated receptors (PPARs), makes it an important tool for studying lipid-mediated regulatory mechanisms. Through such studies, 13(R)-HODE helps explain the complex interactions between lipid metabolism products and cellular signaling pathways, enhancing our understanding of the biochemical pathways that underpin cellular responses to environmental stimuli and internal metabolic changes.