Molecular structure of 12(S)-HETE-d8, CAS Number: 84807-90-9
12(S)-HETE-d8 (CAS 84807-90-9)
Application:
12(S)-HETE-d8 is an internal standard for the quanitification of 12(s)-HETE by LC- or GC- mass spectrometry
CAS Number:
84807-90-9
Purity:
≥99% deuterated product
Molecular Weight:
328.5
Molecular Formula:
C20H24D8O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
12(S)-HETE-d8 contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14 and 15 positions. It is intended for use as an internal standard for the quantification of 12(S)-HETE by GC- or LC-mass spectrometry (MS). 12(S)-HETE is the predominant lipoxygenase product of mammalian platelets. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix at 0.1muM.
12(S)-HETE-d8 (CAS 84807-90-9) References
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- Heart failure is associated with impaired anti-inflammatory and antioxidant properties of high-density lipoproteins. | Kim, JB., et al. 2013. Am J Cardiol. 112: 1770-7. PMID: 24050409
- The development of a specific and sensitive LC-MS-based method for the detection and quantification of hydroperoxy- and hydroxydocosahexaenoic acids as a tool for lipidomic analysis. | Derogis, PB., et al. 2013. PLoS One. 8: e77561. PMID: 24204871
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- Convergence of eicosanoid and integrin biology: Role of Src in 12-LOX activation. | Dilly, AK., et al. 2017. Exp Cell Res. 351: 1-10. PMID: 28011194
- Simultaneous determination of PUFA-derived pro-resolving metabolites and pathway markers using chiral chromatography and tandem mass spectrometry. | Toewe, A., et al. 2018. Anal Chim Acta. 1031: 185-194. PMID: 30119738
- Enantioselective ultra-high performance liquid chromatography-tandem mass spectrometry method based on sub-2µm particle polysaccharide column for chiral separation of oxylipins and its application for the analysis of autoxidized fatty acids and platelet releasates. | Cebo, M., et al. 2020. J Chromatogr A. 1624: 461206. PMID: 32540064
- Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation. | Misheva, M., et al. 2022. Nat Commun. 13: 139. PMID: 35013270
- The Quantitative Profiling of Oxylipins from Arachidonic Acid by LC-MS/MS in Feces at Birth 3 Days and 21 Days of Piglets. | Huang, N., et al. 2022. Metabolites. 12: PMID: 36005575
Activator of:
CYP4A12B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
12(S)-HETE-d8, 25 µg | sc-204987 | 25 µg | $325.00 | |||
12(S)-HETE-d8, 50 µg | sc-204987A | 50 µg | $650.00 |