11(S)-HETE (CAS 54886-50-9)

11(S)-HETE, or 11(S)-hydroxyeicosatetraenoic acid, with CAS number 54886-50-9, is a hydroxy fatty acid derived from the oxidation of arachidonic acid, a polyunsaturated fatty acid integral to the metabolism of eicosanoids. This specific metabolite is produced primarily through the action of lipoxygenase enzymes, which introduce a hydroxyl group at the 11th carbon of arachidonic acid. In research, 11(S)-HETE is commonly used to study the complex roles of lipid metabolites in cellular signaling pathways. Its mechanism of action involves modulating the activity of various signaling proteins and transcription factors, which can influence cellular responses such as migration, differentiation, and response to physical or environmental stress. The compound serves as a crucial tool for scientists exploring the regulation of lipid signaling molecules and their role in cell biology outside of clinical contexts. For instance, studies have applied 11(S)-HETE to understand the biochemical pathways involved in lipid metabolism and its interactions with other cellular components in model organisms. This research helps delineate the broader physiological roles of eicosanoids and their derivatives, enhancing our understanding of fundamental cellular processes and their implications in systems ranging from microbial to plant biology.