Molecular structure of 11-deoxy-16,16-dimethyl Prostaglandin E2, CAS Number: 53658-98-3
11-deoxy-16,16-dimethyl Prostaglandin E2 (CAS 53658-98-3)
Alternate Names:
11-deoxy-16,16-dimethyl PGE2
Application:
11-deoxy-16,16-dimethyl Prostaglandin E2 is an analog of PGE2 shown to act as a selective agonist for EP2 & EP3 receptors
CAS Number:
53658-98-3
Purity:
>98%
Molecular Weight:
364.5
Molecular Formula:
C22H36O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A stable synthetic analog of PGE2. Agonist for both EP2 and EP3 receptors.1 An effective inhibitor of gastric acid secretion and ulcer formation in the rat, with ED50 values of 1 mg/kg and 0.021 mg/kg respectively.2 It is 900 times more potent than PGF2α in the contraction of human respiratory tract smooth muscle in vitro.3
11-deoxy-16,16-dimethyl Prostaglandin E2 (CAS 53658-98-3) References
- DDM-PGE(2)-mediated cytoprotection in renal epithelial cells by a thromboxane A(2) receptor coupled to NF-kappaB. | Weber, TJ., et al. 2000. Am J Physiol Renal Physiol. 278: F270-8. PMID: 10662731
- Prostaglandin E(2)-induced interleukin-6 release by a human airway epithelial cell line. | Tavakoli, S., et al. 2001. Am J Physiol Lung Cell Mol Physiol. 280: L127-33. PMID: 11133502
- 11-Deoxy,16,16-dimethyl prostaglandin E2 induces specific proteins in association with its ability to protect against oxidative stress. | Towndrow, KM., et al. 2003. Chem Res Toxicol. 16: 312-9. PMID: 12641431
- Grp78 is essential for 11-deoxy-16,16-dimethyl PGE2-mediated cytoprotection in renal epithelial cells. | Jia, Z., et al. 2004. Am J Physiol Renal Physiol. 287: F1113-22. PMID: 15226156
- EP1- and EP3-receptors mediate prostaglandin E2-induced constriction of porcine large cerebral arteries. | Jadhav, V., et al. 2004. J Cereb Blood Flow Metab. 24: 1305-16. PMID: 15625406
- Interaction of prostanoid EP₃ and TP receptors in guinea-pig isolated aorta: contractile self-synergism of 11-deoxy-16,16-dimethyl PGE₂. | Jones, RL. and Woodward, DF. 2011. Br J Pharmacol. 162: 521-31. PMID: 20955363
- Prostaglandin E2 differentially modulates human platelet function through the prostanoid EP2 and EP3 receptors. | Petrucci, G., et al. 2011. J Pharmacol Exp Ther. 336: 391-402. PMID: 21059804
- Inhibition of gastric acid secretion and ulcer formation in the rat by orally-administered 11-deoxyprostaglandin analogues: 15-hydroxy-16,16-dimethyl-9-oxoprost-5,13-dienoic acids. | Lippmann, W. 1974. Prostaglandins. 7: 231-46. PMID: 4413891
- Prostaglandins and human respiratory tract smooth muscle: structure activity relationship. | Karim, SM., et al. 1980. Adv Prostaglandin Thromboxane Res. 7: 969-80. PMID: 7369062
- Prostaglandin E2 alters human orbital fibroblast shape through a mechanism involving the generation of cyclic adenosine monophosphate. | Wang, HS., et al. 1995. J Clin Endocrinol Metab. 80: 3553-60. PMID: 8530598
- Effect of prostaglandins on cultured porcine iris sphincter muscle cells. | Fujimoto, N. and Shichi, H. 1996. J Ocul Pharmacol Ther. 12: 343-51. PMID: 8875341
- Effects of centrally administered prostaglandin EP receptor agonists on febrile and adrenocortical responses in the prepubertal pig. | Parrott, RF. and Vellucci, SV. 1996. Brain Res Bull. 41: 97-103. PMID: 8879673
- PGE2-mediated cytoprotection in renal epithelial cells: evidence for a pharmacologically distinct receptor. | Weber, TJ., et al. 1997. Am J Physiol. 273: F507-15. PMID: 9362328
Activator of:
EP2, and EP3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
11-deoxy-16,16-dimethyl Prostaglandin E2, 1 mg | sc-204968 | 1 mg | $92.00 | |||
11-deoxy-16,16-dimethyl Prostaglandin E2, 5 mg | sc-204968A | 5 mg | $415.00 |