Molecular structure of 10-Deacetylbaccatin-III, CAS Number: 32981-86-5
10-Deacetylbaccatin-III (CAS 32981-86-5)
Alternate Names:
Baccatin III, 10-Deacetyl-; 10-DB III
Application:
10-Deacetylbaccatin-III is an intermediate for taxol analog preparations
CAS Number:
32981-86-5
Molecular Weight:
544.6
Molecular Formula:
C29H36O10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
10-Deacetylbaccatin-III is an intermediate for taxol analog preparations. Taxols have exhibit antitumor agents. Several of these taxols can be synthesized from 10- Deacetylbaccatin-III.
10-Deacetylbaccatin-III (CAS 32981-86-5) References
- Enzymatic acetylation of 10-deacetylbaccatin III to baccatin III by C-10 deacetylase from Nocardioides luteus SC 13913. | Patel, RN., et al. 2000. Enzyme Microb Technol. 27: 371-375. PMID: 10938416
- Solid-phase extraction and simplified high-performance liquid chromatographic determination of 10-deacetylbaccatin III and related taxoids in yew species. | Mroczek, T. and Glowniak, K. 2001. J Pharm Biomed Anal. 26: 89-102. PMID: 11451646
- Conversion of taxane glycosides to 10-deacetylbaccatin III. | Yang, T., et al. 2006. Nat Prod Res. 20: 119-24. PMID: 16319004
- Enzymatic C-4 deacetylation of 10-deacetylbaccatin III. | Hanson, RL., et al. 2006. Biotechnol Appl Biochem. 45: 81-5. PMID: 16722823
- Molecular cloning and heterologous expression of a 10-deacetylbaccatin III-10-O-acetyl transferase cDNA from Taxus x media. | Guo, B., et al. 2007. Mol Biol Rep. 34: 89-95. PMID: 17094009
- In vitro activity of 10-deacetylbaccatin III against Leishmania donovani promastigotes and intracellular amastigotes. | Georgopoulou, K., et al. 2007. Planta Med. 73: 1081-8. PMID: 17691059
- Separation of 7-xylosyl-10-deacetyl paclitaxel and 10-deacetylbaccatin III from the remainder extracts free of paclitaxel using macroporous resins. | Fu, Y., et al. 2008. J Chromatogr A. 1177: 77-86. PMID: 18054030
- Bioproduction of baccatin III, an advanced precursor of paclitaxol, with transgenic Flammulina velutipes expressing the 10-deacetylbaccatin III-10-O-acetyl transferase gene. | Han, F., et al. 2014. J Sci Food Agric. 94: 2376-83. PMID: 24403190
- Comparison of Pharmacokinetics and Biodistribution of 10-Deacetylbaccatin III after Oral Administration as Pure Compound or in Taxus chinensis Extract: A Pilot Study. | Zhang, X., et al. 2016. Planta Med. 82: 230-7. PMID: 26838275
- Organocatalytic Site-Selective Acylation of 10-Deacetylbaccatin III. | Yanagi, M., et al. 2016. Chem Pharm Bull (Tokyo). 64: 907-12. PMID: 26903156
- The Combination Process for Preparative Separation and Purification of Paclitaxel and 10-Deacetylbaccatin III Using Diaion® Hp-20 Followed by Hydrophilic Interaction Based Solid Phase Extraction. | Shirshekanb, M., et al. 2017. Iran J Pharm Res. 16: 1396-1404. PMID: 29552048
- Construction of acetyl-CoA and DBAT hybrid metabolic pathway for acetylation of 10-deacetylbaccatin III to baccatin III. | Wang, H., et al. 2021. Acta Pharm Sin B. 11: 3322-3334. PMID: 34729319
- Biosynthesis of taxol: enzymatic acetylation of 10-deacetylbaccatin-III to baccatin-III in crude extracts from roots of Taxus baccata. | Zocher, R., et al. 1996. Biochem Biophys Res Commun. 229: 16-20. PMID: 8954077
- Separation and purification of 10-deacetylbaccatin III by high-speed counter-current chromatography. | Cao, X., et al. 1998. J Chromatogr A. 813: 397-401. PMID: 9700932
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
10-Deacetylbaccatin-III, 5 mg | sc-204607 | 5 mg | $174.00 | |||
10-Deacetylbaccatin-III, 25 mg | sc-204607A | 25 mg | $523.00 |