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1-O-Hexadecyl-2-O-acetyl-sn-glycerol (CAS 77133-35-8)

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Application:
1-O-Hexadecyl-2-O-acetyl-sn-glycerol is an inhibitor of protein kinase C activation
CAS Number:
77133-35-8
Purity:
≥95%
Molecular Weight:
358.6
Molecular Formula:
C21H42O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1-O-Hexadecyl-2-O-acetyl-sn-glycerol, known as platelet-activating factor (PAF) analog, is an ether lipid molecule that mimics the structure and function of the natural bioactive lipid PAF. This compound is widely utilized in biological research to study inflammatory responses and signal transduction pathways associated with PAF. Due to its structural similarity to PAF, 1-O-Hexadecyl-2-O-acetyl-sn-glycerol can bind to the PAF receptor, eliciting or inhibiting cellular responses depending on its specific configuration and experimental context. Research involving 1-O-Hexadecyl-2-O-acetyl-sn-glycerol facilitates the understanding of PAF receptor-mediated processes, which include platelet aggregation, leukocyte activation, and vascular permeability changes. It also helps in investigating the role of PAF in various physiological and pathophysiological contexts. Furthermore, 1-O-Hexadecyl-2-O-acetyl-sn-glycerol is valuable in the development of PAF receptor antagonists and in the study of lipid-mediated cellular communication.


1-O-Hexadecyl-2-O-acetyl-sn-glycerol (CAS 77133-35-8) References

  1. Regulation of the synthesis of platelet-activating factor and its inactive storage precursor (1-alkyl-2-acyl-sn-glycero-3-phosphocholine) from 1-alkyl-2-acetyl-sn-glycerol by rabbit platelets.  |  Lee, TC., et al. 1990. J Biol Chem. 265: 9181-7. PMID: 2160964
  2. Chemoproteomic discovery of AADACL1 as a regulator of human platelet activation.  |  Holly, SP., et al. 2013. Chem Biol. 20: 1125-34. PMID: 23993462
  3. Bacterial exploitation of phosphorylcholine mimicry suppresses inflammation to promote airway infection.  |  Hergott, CB., et al. 2015. J Clin Invest. 125: 3878-90. PMID: 26426079
  4. Alkyl-linked diglycerides inhibit protein kinase C activation by diacylglycerols.  |  Daniel, LW., et al. 1988. Biochem Biophys Res Commun. 151: 291-7. PMID: 3348778
  5. Is there an interplay between the SARS-CoV-2 spike protein and Platelet-Activating factor?  |  Antonopoulou, S., et al. 2022. Biofactors. 48: 1271-1283. PMID: 35852257
  6. Metabolism of 1-O-alkyl-2-acetyl-sn-glycerol by washed rabbit platelets: formation of platelet activating factor.  |  Satouchi, K., et al. 1984. Arch Biochem Biophys. 234: 318-21. PMID: 6486825
  7. 1-0-Hexadecyl-2-acetyl-sn-glycerol stimulates differentiation of HL-60 human promyelocytic leukemia cells to macrophage-like cells.  |  McNamara, MJ., et al. 1984. Biochem Biophys Res Commun. 122: 824-30. PMID: 6590040

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1-O-Hexadecyl-2-O-acetyl-sn-glycerol, 5 mg

sc-200516
5 mg
$177.00