Date published: 2025-10-19

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1-Methyl-2-phenylindole (CAS 3558-24-5)

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Application:
1-Methyl-2-phenylindole is a chromophore intermediate
CAS Number:
3558-24-5
Molecular Weight:
207.27
Molecular Formula:
C15H13N
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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1-Methyl-2-phenylindole is a compound that functions as a reagent in organic synthesis, in the formation of indole derivatives. It acts as a nucleophile in various reactions, such as the Fischer indole synthesis, where it reacts with electrophiles to form indole compounds. The mechanism of action involves the nucleophilic attack of the indole nitrogen on the electrophilic carbon of the reactant, leading to the formation of the desired indole derivative. 1-Methyl-2-Phenylindole is for its ability to facilitate the synthesis of complex organic molecules by participating in key steps of the reaction mechanism. Its role in the formation of indole derivatives may be useful in the development of new compounds for various purposes.


1-Methyl-2-phenylindole (CAS 3558-24-5) References

  1. Reactions of indoles with nitrogen dioxide and nitrous acid in an aprotic solvent.  |  Astolfi, P., et al. 2006. Org Biomol Chem. 4: 3282-90. PMID: 17036116
  2. Evaluation of the 1-methyl-2-phenylindole colorimetric assay for aldehydic lipid peroxidation products in plants: malondialdehyde and 4-hydroxynonenal.  |  Johnston, JW., et al. 2007. Plant Physiol Biochem. 45: 108-12. PMID: 17344056
  3. Synthesis of 3- and 6-sulfonylindoles from ortho-alkynyl-N-sulfonylanilines by the use of Lewis acidic transition-metal catalysts.  |  Nakamura, I., et al. 2008. Chem Asian J. 3: 285-95. PMID: 18046686
  4. Estimation of lipid peroxidation induced by hydrogen peroxide in cultured human lymphocytes.  |  Siddique, YH., et al. 2012. Dose Response. 10: 1-10. PMID: 22423225
  5. Plasma malondialdehyde as biomarker of lipid peroxidation: effects of acute exercise.  |  Spirlandeli, AL., et al. 2014. Int J Sports Med. 35: 14-8. PMID: 23771832
  6. Validation of 1-methyl-2-phenylindole method for estimating lipid peroxidation in the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ)Bg (9.).  |  Siddique, YH., et al. 2012. Pharm Methods. 3: 94-7. PMID: 23781486
  7. Identification of 3-Bromo-1-Ethyl-1H-Indole as a Potent Anticancer Agent with Promising Inhibitory Effects on GST Isozymes.  |  Yılmaz, C., et al. 2021. Anticancer Agents Med Chem. 21: 1292-1300. PMID: 32951581
  8. Cytotoxicity of Ficus Crocata Extract on Cervical Cancer Cells and Protective Effect against Hydrogen Peroxide-Induced Oxidative Stress in HaCaT Non-Tumor Cells.  |  De la Cruz-Concepción, B., et al. 2021. Plants (Basel). 10: PMID: 33478134
  9. Reactions of 1-methyl-2-phenylindole with malondialdehyde and 4-hydroxyalkenals. Analytical applications to a colorimetric assay of lipid peroxidation.  |  Gérard-Monnier, D., et al. 1998. Chem Res Toxicol. 11: 1176-83. PMID: 9778314

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

1-Methyl-2-phenylindole, 10 g

sc-253936
10 g
$30.00